Article

[Regulatory mechanism of incretin secretion].

Division of Cellular and Molecular Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine.
Nippon rinsho. Japanese journal of clinical medicine 05/2011; 69(5):803-7. pp.803-7
Source: PubMed

ABSTRACT Incretin hormones GIP(glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) improve glycemic control by potentiating glucose-induced insulin secretion in pancreatic beta-cells and also have beneficial effects on appetite control and body weight. In response to food ingestion, GIP and GLP-1 are secreted from enteroendocrine K- and L-cells, respectively. In these cells, it is shown that a variety of molecular sensors are involved in the detection of carbohydrates, lipids, and proteins. In view of development of new incretin-related drugs, these sensors are attractive targets to enhance the endogenous pools of incretins.

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Keywords

appetite control
 
body weight
 
endogenous pools
 
enteroendocrine K-
 
food ingestion
 
glycemic control
 
Incretin hormones GIP(glucose-dependent insulinotropic polypeptide)
 
lipids
 
molecular sensors
 
new incretin-related drugs
 
pancreatic beta-cells
 
potentiating glucose-induced insulin secretion
 

Tadao Shibasaki