Article

Chondroitinase ABC treatment and the phenotype of neural progenitor cells isolated from injured rat spinal cord.

Institute of Neurobiology, CE, Slovak Academy of Sciences, Košice, Slovakia.
Physiological research / Academia Scientiarum Bohemoslovaca (impact factor: 1.55). 05/2011; 60(4):705-8. pp.705-8
Source: PubMed

ABSTRACT The aim of the present study was to investigate whether enzyme chondroitinase ABC (ChABC) treatment influences the phenotype of neural progenitor cells (NPCs) derived from injured rat spinal cord. Adult as well as fetal spinal cords contain a pool of endogenous neural progenitors cells, which play a key role in the neuroregenerative processes following spinal cord injury (SCI) and hold particular promise for therapeutic approaches in CNS injury or neurodegenerative disorders. In our study we used in vitro model to demonstrate the differentiation potential of NPCs isolated from adult rat spinal cord after SCI, treated with ChABC. The intrathecal delivery of ChABC (10 U/ml) was performed at day 1 and 2 after SCI. The present findings indicate that the impact of SCI resulted in a decrease of all NPCs phenotypes and the ChABC treatment, on the contrary, caused an opposite effect.

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Keywords

adult rat spinal cord
 
ChABC
 
ChABC treatment
 
decrease
 
endogenous neural progenitors cells
 
enzyme chondroitinase ABC
 
fetal spinal cords
 
intrathecal delivery
 
neural progenitor cells
 
neurodegenerative disorders
 
neuroregenerative processes
 
NPCs
 
NPCs phenotypes
 
particular promise
 
rat spinal cord
 
spinal cord injury
 
therapeutic approaches
 
vitro model