Article

Increasing prevalence of gestational diabetes mellitus in Chinese women from 1999 to 2008

Tianjin Women's and Children's Health Center, Tianjin, China.
Diabetic Medicine (Impact Factor: 3.06). 06/2011; 28(6):652-7. DOI: 10.1111/j.1464-5491.2010.03205.x
Source: PubMed

ABSTRACT To investigate the trend in the prevalence of gestational diabetes mellitus during 1999-2008 in women living in urban Tianjin, China.
A universal screening for gestational diabetes mellitus has become an integral part of the antenatal care in Tianjin, China from 1998. A total of 105,473 pregnant women living in the six urban districts of Tianjin, China, participated in the gestational diabetes mellitus screening programme between December 1998 and December 2008. The screening test consisted of a 50-g 1-h glucose test. Women who had a glucose reading ≥7.8 mmol/l at the initial screening were invited to undergo the standard 2-h oral glucose tolerance test with a 75-g glucose load. Gestational diabetes mellitus was confirmed using the World Health Organization's diagnostic criteria.
The adjusted prevalence of gestational diabetes mellitus increased by 2.8 times during 1999-2008, from 2.4 to 6.8% (P<0.0001 for linear trend). In 2008, the age-specific prevalence of gestational diabetes mellitus was the highest among women aged 30-34 years (11.3%) and lowest among women aged 25 and under (1.2%). In women aged 35 years and more, the prevalence was 5.3%.
The prevalence of gestational diabetes mellitus has markedly been increasing in a universally screened urban Chinese female population and has become an important public health problem in China.

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Available from: Gang Hu, Jul 30, 2015
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    • "Gestational diabetes mellitus (GDM) is increasingly common in the US and around the world [1]. In China, the prevalence of GDM has increased from 2.4% in 1999 to 6.8% in 2008, now close to the US level [2]. One of the major concerns about GDM is that it may be contributing to a vicious intergenerational cycle of obesity and diabetes [3]. "
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    ABSTRACT: To evaluate the association of maternal fasting glucose levels at 4-12 gestational weeks with anthropometry in the offspring from birth to 12 months in Tianjin, China. A total of 57,454 pregnant women underwent a fasting glucose test during the first trimester, and their children had body weight/length measured from birth to 12 months of age. Maternal fasting glucose concentrations at 4-12 gestational weeks were positively associated with Z scores for birth weight, birth length, birth weight for length, and birth body mass index (BMI). Infants born to mothers with fasting glucose concentrations ≥126mg/dL (7.0mmol/l) had had the highest mean Z scores for birth weight, birth length, birth weight for length and birth BMI for gestational age, and the lowest mean Z scores for weight and length for age at months 3, 6, 9, and 12, the smallest changes in Z scores for weight for age, weight for length, and BMI for age from birth to month 3, and largest changes in Z scores for weight for age, and BMI for age after 6 months. Higher maternal fasting glucose during pregnancy was associated with larger birth weight and birth length, less weight gain and length gain in the first 3 months of life, and more weight gain in months 6-12 of life.
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    • "We have been using the World Health Organization (WHO)'s criteria [18] to define GDM [7]. Women with a 75-g glucose 2-h OGTT result confirming either diabetes (fasting glucose !7 mmol/l or 2-h glucose !11.1 mmol/l) or IGT (2-h glucose !7.8 and <11.1 mmol/l) are regarded as having GDM [7]. A total of 128,125 pregnant women took part in the GDM screening program and 6247 were diagnosed with GDM from December 1998 to December 2009. "
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    ABSTRACT: To examine the association of maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) with anthropometry in the offspring of mothers with gestational diabetes mellitus (GDM). We performed a retrospective cohort study in 1263 GDM mother-child pairs. General linear models and Logistic regression models were used to assess the single and joint associations of maternal pre-pregnancy BMI (normal weight, overweight, and obesity) and GWG (inadequate, adequate and excessive GWG) with anthropometry and overweight status in the offspring from birth to 1-5 years old. Maternal pre-pregnancy BMI and GWG were positively associated with birth weight for gestational age Z score and birth weight for length for gestational age Z score at birth, and weight for age Z score, length/height for age Z score, and weight for length/height Z score at of 1-5 years old offspring. Maternal pre-pregnancy overweight, obesity, and excessive GWG were associated with increased risks of large for gestational age [ORs 95% CIs = 1.87 (1.37-2.55), 2.98 (1.89-4.69), and 2.93 (2.07-4.13), respectively] and macrosomia [ORs 95% CIs = 2.06 (1.50-2.84), 2.89 (1.78-4.70), and 2.84 (1.98-4.06), respectively] at birth and childhood overweight at 1-5 years old [ORs 95% CIs = 1.26 (0.92-1.73), 1.96 (1.24-3.09), and 1.59 (1.15-2.21), respectively]. Offspring born to GDM mothers with pre-pregnancy overweight/obesity or excessive GWG were associated with increased risks of large for gestational age and macrosomia at birth, and childhood overweight at 1-5 years old, compared with those born to GDM mothers with pre-pregnancy normal weight and adequate GWG.
    PLoS ONE 10(6):e0129536. DOI:10.1371/journal.pone.0129536 · 3.53 Impact Factor
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