Eukaryotic type translation initiation factor 2: Structure-functional aspects

Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
Biochemistry (Moscow) (Impact Factor: 1.3). 03/2011; 76(3):283-94. DOI: 10.1134/S0006297911030011
Source: PubMed


Translation initiation factor 2 (IF2) is one of key components of the translation initiation system in living cells. In bacteria IF2 is a multidomain monomeric protein, while in eukaryotic and archaean cells e/aIF2 is heterotrimer (αβγ). Data, including our own, on eukaryotic type translation initiation factor 2 (e/aIF2) structure and functioning are presented. There are also new data on initiation factors eIF5 and eIF2B that directly interact with eIF2 and control its participation in nucleotide exchange.

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