[Detection and clinical significance of MCP-1 in gingival crevicular fluid from patients with chronic periodontitis].
ABSTRACT To evaluate the concentration of monocyte chemoattractant protein-1 (MCP-1) in the gingival crevicular fluid from patients with chronic periodontitis and its correlation with clinic periodontal parameters as well as alkaline phosphates secretions.
Gingival crevicular fluid (GCF) was collected with standardized filter strips from healthy control sites as well as periodontitis sites from chronic periodontitis patients before and after initial therapy, and the levels of MCP-1 and alkaline phosphatase were detected by ELISA. The data was analyzed with SPSS 11.0 software package.
Concentration of MCP-1 in GCF was significantly higher in chronic periodontitis patients, and decreased significantly after initial therapy, the variation of MCP-1 correlated positively with clinical parameters like plaque index(PLI), probing depth (PD), gingival index (GI), clinic attachment lost (CAL) as well as alkaline phosphatase secretion.
As an inflammatory chemotatic factor, MCP-1 in GCF may play an important role in occurrence and development of chronic periodontitis, and could be considered as a potential target for prevention and treatment of chronic periodontitis.