Article

[Detection and clinical significance of MCP-1 in gingival crevicular fluid from patients with chronic periodontitis].

Department of Stomatology, First People's Hospital, Shanghai Jiao Tong University, Shanghai 200011, China.
Shanghai kou qiang yi xue = Shanghai journal of stomatology 04/2011; 20(2):183-6. pp.183-6
Source: PubMed

ABSTRACT To evaluate the concentration of monocyte chemoattractant protein-1 (MCP-1) in the gingival crevicular fluid from patients with chronic periodontitis and its correlation with clinic periodontal parameters as well as alkaline phosphates secretions.
Gingival crevicular fluid (GCF) was collected with standardized filter strips from healthy control sites as well as periodontitis sites from chronic periodontitis patients before and after initial therapy, and the levels of MCP-1 and alkaline phosphatase were detected by ELISA. The data was analyzed with SPSS 11.0 software package.
Concentration of MCP-1 in GCF was significantly higher in chronic periodontitis patients, and decreased significantly after initial therapy, the variation of MCP-1 correlated positively with clinical parameters like plaque index(PLI), probing depth (PD), gingival index (GI), clinic attachment lost (CAL) as well as alkaline phosphatase secretion.
As an inflammatory chemotatic factor, MCP-1 in GCF may play an important role in occurrence and development of chronic periodontitis, and could be considered as a potential target for prevention and treatment of chronic periodontitis.

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Keywords

alkaline phosphatase
 
alkaline phosphatase secretion
 
alkaline phosphates secretions
 
chronic periodontitis
 
chronic periodontitis patients
 
clinic attachment
 
clinic periodontal parameters
 
clinical parameters
 
ELISA
 
GI
 
gingival crevicular fluid
 
gingival index
 
healthy control sites
 
inflammatory chemotatic factor
 
initial therapy
 
patients
 
periodontitis sites
 
potential target
 
SPSS 11.0 software package
 
standardized filter strips
 

Zun Zhang