Estrogen Receptor Transrepresses Brain Inflammation

Laboratory of Endocrinology and Genomics, CHUQ Research Center and Department of Molecular Medicine, Faculty of Medicine, Laval University, 2705 Laurier Boulevard, Québec, G1V 4G2, Canada.
Cell (Impact Factor: 32.24). 05/2011; 145(4):495-7. DOI: 10.1016/j.cell.2011.04.018
Source: PubMed


Estrogen receptors (ERs) have long been implicated in the etiology of multiple sclerosis, but no clear molecular mechanisms have linked ERs to the disease's pathology. Now Saijo et al. (2011) provide evidence that ERβ activates a transrepression pathway that suppresses inflammation and inhibits progression of pathology in a mouse model of multiple sclerosis.

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    • "Consequently, treatment with ERb-specific ligands conferred neuroprotection against experimentally induced autoimmune encephalomyelitis (EAE), a murine model for multiple sclerosis (MS) (Saijo et al., 2011). Thus, the progression of MS, and possibly other autoimmune disorders of the brain, could potentially be linked to a dysregulated ERb transrepression pathway (Gosselin and Rivest, 2011). 3.2. "
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