ChemInform Abstract: Gram Scale Synthesis of 3-Fluoro-1-hydroxyacetone Phosphate: A Novel Donor Substrate in Rabbit Muscle Aldolase-Catalyzed Aldol Reactions.
Department of Organic Chemistry, University of Vienna, Währingerstrasse 38, 1090 Vienna, Austria.Chemical Communications (Impact Factor: 6.83). 06/2011; 47(23):6647-9. DOI: 10.1039/c1cc11579k
An efficient gram scale synthesis of 3-fluoro-1-hydroxyacetone phosphate (FHAP) has been developed. As a close analog to dihydroxyacetone phosphate, FHAP was used as a novel donor substrate for rabbit muscle aldolase catalyzed reactions. The different binding affinities of the gem-diol and keto form of FHAP were studied by (19)F-NMR.
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.