ChemInform Abstract: Gram Scale Synthesis of 3-Fluoro-1-hydroxyacetone Phosphate: A Novel Donor Substrate in Rabbit Muscle Aldolase-Catalyzed Aldol Reactions.

Department of Organic Chemistry, University of Vienna, Währingerstrasse 38, 1090 Vienna, Austria.
Chemical Communications (Impact Factor: 6.83). 06/2011; 47(23):6647-9. DOI: 10.1039/c1cc11579k
Source: PubMed


An efficient gram scale synthesis of 3-fluoro-1-hydroxyacetone phosphate (FHAP) has been developed. As a close analog to dihydroxyacetone phosphate, FHAP was used as a novel donor substrate for rabbit muscle aldolase catalyzed reactions. The different binding affinities of the gem-diol and keto form of FHAP were studied by (19)F-NMR.

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