Article

Gram scale synthesis of 3-fluoro-1-hydroxyacetone phosphate: a novel donor substrate in rabbit muscle aldolase-catalyzed aldol reactions.

Department of Organic Chemistry, University of Vienna, Währingerstrasse 38, 1090 Vienna, Austria.
Chemical Communications (impact factor: 6.17). 06/2011; 47(23):6647-9. DOI:10.1039/c1cc11579k pp.6647-9
Source: PubMed

ABSTRACT An efficient gram scale synthesis of 3-fluoro-1-hydroxyacetone phosphate (FHAP) has been developed. As a close analog to dihydroxyacetone phosphate, FHAP was used as a novel donor substrate for rabbit muscle aldolase catalyzed reactions. The different binding affinities of the gem-diol and keto form of FHAP were studied by (19)F-NMR.

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Keywords

3-fluoro-1-hydroxyacetone phosphate
 
different binding affinities
 
dihydroxyacetone phosphate
 
efficient gram scale synthesis
 
novel donor substrate
 
rabbit muscle aldolase catalyzed reactions
 

Michael Fischer