A chemoenzymatic synthesis of 5a-carba-α-D-mannose-6-phosphate

School of Chemistry and Chemical Engineering, David Kerr Building, Queen's University Belfast, Stranmillis Rd, Belfast BT9 5DG, United Kingdom.
Carbohydrate research (Impact Factor: 1.93). 07/2011; 346(10):1257-61. DOI: 10.1016/j.carres.2011.04.011
Source: PubMed


An efficient chemical synthesis of 5a-carba-α-D-mannose and its enzymatic elaboration to 5a-carba-α-D-mannose-6-phosphate, using yeast hexokinase, is described.

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