The role of caregiver major depression in the relationship between anxiety disorders and asthma attacks in island Puerto Rican youth and young adults.

Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY 10461, USA.
The Journal of nervous and mental disease (Impact Factor: 1.81). 05/2011; 199(5):313-8. DOI: 10.1097/NMD.0b013e3182174e84
Source: PubMed

ABSTRACT The goal of this study was to assess whether the association between asthma attacks and anxiety disorders in youth/young adults is reduced after adjusting for the caregivers' psychiatric disorders. An island-wide probability sample of 641 households in Puerto Rico with youth/young adults between ages 10 and 25 years participated along with their caregivers. The Diagnostic Interview Schedule for Children and the Composite International Diagnostic Interview were conducted to assess anxiety and depressive disorders. Youth/young adults with an anxiety disorder were more likely to have a lifetime history of asthma attacks versus youth/young adults without an anxiety disorder. Caregivers of participants with asthma attacks were more likely to have major depression than did the caregivers of participants without asthma attacks. The association between asthma attacks and anxiety disorders in youth was no longer significant after adjustment for caregiver major depression. It is important to consider the role of caregiver depression in asthma-anxiety comorbidity in youth/young adults.


Available from: Alexander N Ortega, Jun 10, 2015
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    ABSTRACT: Background Depression is often present in patients with asthma and vice versa. In this review, we aimed to summarize reports on the comorbidity of depression and asthma, and to seek evidence that the biological mechanisms of allergy may have an important role linking asthma and depression. Method To explore the relationship and pathway underpinning this comorbidity, we reviewed medical articles and undertook a meta-analysis of epidemiological studies on (i) incidence of asthma in patients with depression; (ii) morbidity of depression in patients with asthma; (iii) concentration of cytokines in depressed subjects. Results High level of comorbidity of asthma and depression was consistently demonstrated in 10 studies of patients with asthma and four studies of patients with depression. In search of biological connection of the two illnesses, thirty-eight studies were included for Meta-analyses examining differences in allergy related cytokines between patients with depression and non-depressive subjects. In people with depression, concentration of monocytes related cytokines such as IL-1 (1.56 ng/mL, 95% CI: 0.00–3.12, p=0.05) was significantly higher than that in non-depressive control subjects. At the same time, some other inflammatory factors including IL-4 (5.77 pg/mL, 95% CI: 2.34–9.21, p=0.00010), IL-6 (1.44 ng/mL, 95% CI: 1.05–1.82, p<0.00001) and TNF-α(3.01 ng/mL, 95% CI: 1.76–4.26, p<0.00001) were extremely significantly higher in depressed people compared with the controls. There was no significant differences of the T cell related cytokine levels, IFN-γ (−0.16 ng/mL, 95% CI: −0.85–7.73, p=0.97), accompanied with IL-10 (0.67 ng/mL, 95% CI: −0.84–2.18, p=0.38) between depressive and non-depressive groups. Conclusions The varying levels of certain cytokines play an important role in arousing and remitting asthma and depression. That suggests inflammatory response could be a common pathway adjusting both depression and asthma.
    Journal of Affective Disorders 09/2014; 166:22–29. DOI:10.1016/j.jad.2014.04.027 · 3.71 Impact Factor
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    Dataset: Noriega
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    ABSTRACT: This study aims at determining whether there was an association among anxiety, depression and allergic illnesses. It suggests the proper therapeutic treatment. During a year, our research work team worked with a group of 82 female and male patients (from 13 to 76 years old) who suffered from various types of allergies. Two psychometric scales were used to carry out this study: Hamilton's scale for anxiety whereas Beck Depression Inventory (BDI-II) and Zung's for depression. The association and its percentage were analyzed in patients who reported typical symptoms during their first check-up. They were free of psychopharmacologic drugs and psychotherapies. The presence of anxiety and depression was interpreted as another factor in the development of allergic symptoms. The following results were achieved as regards: for anxiety, an association positive 95 %. For depression, the results showed that there was a positive tendency for the association with an allergic illness. The conclusions showed that there is a positive association between anxiety and allergies. As regards depression and allergic illness, there is only a positive tendency. These final results would raise awareness of how to deal with anxiety and depression in allergic patients, both psychopharmacologically and psychotherapeutically.
    Vertex (Buenos Aires, Argentina) 07/2013; XXIV(110):253-258.