Article

Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease.

Department of Neurology and Immunobiology, Yale School of Medicine, New Haven, Connecticut, USA.
Nature medicine (impact factor: 27.14). 06/2011; 17(6):673-5. DOI:10.1038/nm.2389
Source: PubMed

ABSTRACT CD4(+)CD25(high)CD127(low/-) forkhead box p3 (Foxp3)(+) regulatory T cells (T(reg) cells) possess functional plasticity. Here we describe a higher frequency of T helper type 1 (T(H)1)-like, interferon-γ (IFN-γ)-secreting Foxp3(+) T cells in untreated subjects with relapsing remitting multiple sclerosis (RRMS) as compared to healthy control individuals. In subjects treated with IFN-β, the frequency of IFN-γ(+)Foxp3(+) T cells is similar to that in healthy control subjects. In vitro, human T(reg) cells from healthy subjects acquire a T(H)1-like phenotype when cultured in the presence of interleukin-12 (IL-12). T(H)1-like T(reg) cells show reduced suppressive activity in vitro, which can partially be reversed by IFN-γ-specific antibodies or by removal of IL-12.

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    Article: Immunoregulation in cutaneous allergy: prevention and control.
    Christina E Zielinski, Torsten Zuberbier, Marcus Maurer
    [show abstract] [hide abstract]
    ABSTRACT: The cutaneous surface is exposed to a myriad of encounters with chemicals, allergens and microbes. Nevertheless, it withstands these environmental assaults without overt inflammation. We will discuss the role of T regulatory cells in a situation where this tissue homeostasis fails - cutaneous allergy, in particular contact hypersensitivity. Immune regulation is a complex process that is mediated by many cellular players. T regulatory cells have risen to particular prominence as potent immunosuppressors because their absence results in inflammation including skin allergy. Recent findings revealed that T regulatory cells comprise a heterogeneous group of subpopulations with specialized homing capabilities and suppressor functions. The stability of the T regulatory cell subset in proinflammatory microenvironments is controversially discussed. In addition, it has recently been shown that mechanisms by which T regulatory cells exert their immunosuppressive functions can be adopted by pathogenic effector T cells in certain situations. In cutaneous allergy, immunoregulatory mechanisms are dysfunctional. The cellular players comprise classical T regulatory cells as well as effector T cells with regulatory activities. Understanding their role in skin homeostasis and the mechanisms by which their regulatory functions are abrogated will yield novel therapeutic targets for the treatment of cutaneous allergies.
    Current Opinion in Allergy and Clinical Immunology 07/2012; 12(5):498-503. · 4.11 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

cultured
 
functional plasticity
 
healthy control individuals
 
healthy control subjects
 
healthy subjects
 
human T(reg)
 
IFN-β
 
IFN-γ)-secreting Foxp3(+
 
IFN-γ-specific antibodies
 
interferon-γ
 
interleukin-12
 
relapsing remitting multiple sclerosis
 
suppressive activity
 
T helper type 1
 
T(H)1-like phenotype
 
untreated subjects
 
vitro