Change in sleep duration and cognitive function: findings from the Whitehall II Study.

University College London, Department of Epidemiology and Public Health, London, UK.
Sleep (Impact Factor: 5.1). 05/2011; 34(5):565-73.
Source: PubMed

ABSTRACT Evidence from cross-sectional studies shows that sleep is associated with cognitive function. This study examines change in sleep duration as a determinant of cognitive function.
Prospective cohort.
The Whitehall II study.
1459 women and 3972 men aged 45-69 at baseline.
Sleep duration (≤ 5, 6, 7, 8, ≥ 9 h on an average week night) was assessed once between 1997-1999, baseline for the present study, and once between 2002-2004, average follow-up 5.4 years. Cognitive function was measured (2002-2004) using 6 tests: verbal memory, inductive reasoning (Alice Heim 4-I), verbal meaning (Mill Hill), phonemic and semantic fluency, and the Mini Mental State Examination (MMSE). In analyses adjusted for age, sex, and education, and corrected for multiple testing, adverse changes in sleep between baseline and follow-up (decrease from 6, 7, or 8 h, increase from 7 or 8 h) were associated with lower scores on most cognitive function tests. Exceptions were memory, and, for a decrease from 6-8 h only, phonemic fluency. Further adjustment for occupational position attenuated the associations slightly. However, firm evidence remained for an association between an increase from 7 or 8 h sleep and lower cognitive function for all tests, except memory, and between a decrease from 6-8 h sleep and poorer reasoning, vocabulary, and the MMSE. The magnitude of these effects was equivalent to a 4-7 year increase in age.
These results suggest that adverse changes in sleep duration are associated with poorer cognitive function in the middle-aged.

  • [Show abstract] [Hide abstract]
    ABSTRACT: Disturbed sleep is a prominent feature of posttraumatic stress disorder (PTSD). PTSD and disrupted sleep have been independently linked to cognitive deficits; however, synergistic effects of PTSD and poor sleep on cognition have not been investigated. The purpose of this study was to examine the effects of PTSD symptoms and objectively measured disruptions to sleep on cognitive function. Forty-four young-adult African American urban residents comprised the study sample. The Clinician-Administered PTSD Scale (CAPS; Blake et al., 1995) was utilized to determine the severity of PTSD symptoms. Participants underwent 2 consecutive nights of polysomnography. The Automated Neuropsychological Assessment Metrics (Reeves, Winter, Bleiberg, & Kang, ) was utilized to assess sustained attention and the Rey Auditory Verbal Learning Test (Schmidt, ) was used to evaluate verbal memory. PTSD symptom severity, r(42) = .40, p = .007, was significantly associated with omission errors on the sustained attention task, and sleep duration, r(42) = .41, p = .006, and rapid eye movement sleep, r(42) = .43, p = .003, were positively correlated with verbal memory. There was an interaction of PTSD symptom severity and sleep duration on omission errors such that more than 7 hours 12 minutes of sleep mitigated attentional lapses that were associated with PTSD.Traditional and Simplified Chinese Abstracts by AsianSTSS標題:非裔美國年輕人中創傷後壓力症和睡眠測量與認知表現的關係撮要:睡眠困擾是創傷後壓力左(PTSD)的顯著病癥。PTSD和睡眠問題各自與認知受損有關,但PTSD和失眠對認知的協同效應則未有探討。本研究檢視PTSD症狀的影響和客觀地量度睡眠困擾對認知功能的效果。樣本是53名非裔美國年輕市區居民。醫生施行PTSD量表(CAPS)測量PTSD症狀的嚴重程度,而參加者亦會連續兩晚接受多重睡眠電圖測試。持續注意力會採用自動化神經心理評估指標來評核,而雷伊聽覺言語學習測試則評定言語記憶。PTSD症狀的嚴重程度 r(42)= .40, p= .007統計上顯著與持續注意力任務的遺漏錯誤相連,而睡眠持續時間r(42)= .41, p= .006和快速眼動睡眠r(42)= .43, p= .003均與言語記憶有正相連。PTSD症狀嚴重程度和睡眠持續時間對遺漏錯誤有相互影響,以致多於7小時12分的睡眠可減輕與PTSD相關的注意力失誤。标题:非裔美国年轻人中创伤后压力症和睡眠测量与认知表现的关系撮要:睡眠困扰是创伤后压力左(PTSD)的显著病症。PTSD和睡眠问题各自与认知受损有关,但PTSD和失眠对认知的协同效应则未有探讨。本研究检视PTSD症状的影响和客观地量度睡眠困扰对认知功能的效果。样本是53名非裔美国年轻市区居民。医生施行PTSD量表(CAPS)测量PTSD症状的严重程度,而参加者亦会连续两晚接受多重睡眠电图测试。持续注意力会采用自动化神经心理评估指标来评核,而雷伊听觉言语学习测试则评定言语记忆。PTSD症状的严重程度 r(42)= .40, p= .007统计上显著与持续注意力任务的遗漏错误相连,而睡眠持续时间r(42)= .41, p= .006和快速眼动睡眠r(42)= .43, p= .003均与言语记忆有正相连。PTSD症状严重程度和睡眠持续时间对遗漏错误有相互影响,以致多于7小时12分的睡眠可减轻与PTSD相关的注意力失误。
    Journal of Traumatic Stress 04/2014; 27(2). · 2.72 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: A large number of studies have recently shown effects of sleep on memory consolidation. In this study the effects of the sleep quality and sleep length on the retention of autobiographical memories are examined, using an Internet-based diary technique (Kristo, Janssen, & Murre, 2009). Each of over 600 participants recorded one recent personal event and was contacted after a retention interval that ranged from 2 to 46 days. Recall of the content, time, and details of the event were scored and related to sleep quality and sleep length as measured with the Pittsburgh Sleep Quality Index. Hierarchical regression analyses indicated that poor sleep quality, but not short sleep length, was associated with significantly lower recall at the longer retention periods (30-46 days), but not at the shorter ones (2-15 days), although the difference in recall between good and poor sleepers was small.
    Memory 04/2014; 22(6):633-645. · 2.09 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline that is a growing public health crisis with a prevalence projected to more than double in the next 20 years. Sleep is frequently impaired in individuals with AD. Further, recent studies have linked numerous age-related sleep disturbances such as poor sleep efficiency and sleep apnea, to future risk of cognitive impairment. Aggregation of amyloid-β (Aβ) into extracellular plaques in the brain is a key step in AD pathogenesis and likely begins 20 years before the onset of dementia. Aβ concentrations in both humans and mouse models show Aβ concentrations rise during wakefulness and fall during sleep, that is, an Aβ diurnal pattern. There is evidence in animal models that changes in sleep time alter Aβ deposition, suggesting that sleep may play a role in AD pathogenesis. A hypothetical model for the role of sleep and the Aβ diurnal pattern in AD pathogenesis is proposed.
    Neurobiology of aging. 05/2014;

Full-text (2 Sources)

Available from
May 22, 2014