Cognition in circadian rhythm sleep disorders

Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Progress in brain research (Impact Factor: 2.83). 01/2011; 190:3-20. DOI: 10.1016/B978-0-444-53817-8.00001-3
Source: PubMed


Circadian rhythms in physiology and behavior exist in all living organisms, from cells to humans. The most evident rhythms are the recurrent cycles of sleep and wake as well as changes in alertness and cognitive performance across the 24h. Clearly, sleep pressure can exert a strong influence on cognitive performance, but the influence of circadian modulation of alertness and cognitive function is evident even when the pressure for sleep is high. Circadian rhythms also influence more complex cognitive tasks, such as selective attention and executive function, which are important for work performance and safety. The circadian timekeeping system also ensures that circadian rhythms are appropriately synchronized to the external physical environment and work and social schedules. Circadian misalignment is the basis for all circadian rhythm sleep disorders. These disorders are often associated with impairments of cognitive performance that can have adverse effects on school and work performance, overall quality of life, and safety.

19 Reads
    • "In rats, a deleterious effect of repeated phase shifts on hippocampal (spatial) memory has been observed [108]. In humans, circadian rhythm sleep disorders are often associated with impairments of selective attention and executive function [109]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Sleep disorders are frequent in Alzheimer's disease (AD), with a significant impact on patients and caregivers and a major risk factor for early institutionalization. Micro-architectural sleep alterations, nocturnal sleep fragmentation, decrease in nocturnal sleep duration, diurnal napping and even inversion of the sleep-wake cycle are the main disorders observed in patients with AD. Experimental and epidemiological evidence for a close reciprocal interaction between cognitive decline and sleep alterations is growing. Management of sleep disorders in AD is pre-eminently behavioral. Association of melatonin and bright light treatment seems to be promising as well. The presence of sleep complaints, especially excessive somnolence in demented patients, should draw attention to possible associated sleep pathologies such as sleep apnea syndrome or restless legs syndrome.
    Sleep Medicine Reviews 04/2014; 19. DOI:10.1016/j.smrv.2014.03.007 · 8.51 Impact Factor
  • Source
    • "In healthy subjects, experimentally induced sleep loss is associated with impairments in a broad range of cognitive functions7,8 and people with primary sleep disorders such as insomnia9 and sleep apnea10 also suffer from cognitive impairments. Cognitive performance also follows a well characterized circadian rhythm,11 and people suffering from circadian rhythm disorders also suffer from impairments in cognitive performance.12 "
    [Show abstract] [Hide abstract]
    ABSTRACT: Sleep has been described as being of the brain, by the brain, and for the brain. This fundamental neurobiological behavior is controlled by homeostatic and circadian (24-hour) processes and is vital for normal brain function. This review will outline the normal sleep-wake cycle, the changes that occur during aging, and the specific patterns of sleep disturbance that occur in association with both mental health disorders and neurodegenerative disorders. The role of primary sleep disorders such as insomnia, obstructive sleep apnea, and REM sleep behavior disorder as potential causes or risk factors for particular mental health or neurodegenerative problems will also be discussed.
    Nature and Science of Sleep 05/2013; 5:61-75. DOI:10.2147/NSS.S34842
  • Source
    • "This circadian activity is self-sustaining, and can be synchronized to the local environment. Disruption of these rhythms has detrimental effects on health and cognitive function [1], [2]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: cAMP response element-binding protein (CREB) and nuclear factor kappa-B (NF-κB) are two ubiquitous transcription factors involved in a wide number of cellular processes, including the circadian system. Many previous studies on these factors use cellular assays that provide limited information on circadian activity or anatomical specificity. The ability to study transcription factors in defined tissue within intact animals will help to bridge the gap between cellular and in vivo data. We have used the GAL4-UAS and FLP-FRT systems to gain spatial control over reporter gene expression. Using a luciferase-based reporter, we show in vivo that Drosophila dCREB2- and NF-κB-mediated transcription oscillates in neuronal cells, glia, and in the mushroom body, a higher-order brain center in flies. This oscillation is under circadian control, cycling with a 24-hour rhythm, under both light-dark and dark-dark conditions. In light-light conditions, dCREB2 and NF-κB reporter flies exhibit a suppression of rhythmic activity. Furthermore, neuronal cycling of dCREB2 and NF-κB activity are modulated in period mutant flies, indicating these oscillations are controlled through the central clock. This study shows for the first time region-specific circadian oscillation of dCREB2/NF-κB activity in the Drosophila nervous system.
    PLoS ONE 10/2012; 7(10):e45130. DOI:10.1371/journal.pone.0045130 · 3.23 Impact Factor
Show more

Similar Publications