Markers of Inflammation and Fat Distribution Following Weight Loss in African‐American and White Women

Department of Nutrition Sciences, University of Alabama-Birmingham, Birmingham, Alabama, USA.
Obesity (Impact Factor: 3.73). 04/2011; 20(4):715-20. DOI: 10.1038/oby.2011.85
Source: PubMed


Changes in markers of inflammation (MOI) and fat distribution with weight loss between African-American (AA) and white (W) women have yet to be characterized. The purpose of this study was to examine potential ethnic differences in MOI and regional fat distribution with weight loss, and identify the associations between these markers and changes in regional fat distribution with weight loss among AA and W women. Subjects were 126 healthy, premenopausal women, BMI 27-30 kg/m(2). They were placed on a weight-loss intervention consisting of diet and/or exercise until a BMI <25 was achieved. Fat distribution was measured with computed tomography, and body composition with dual-energy X-ray absorptiometry. Serum concentrations of tumor necrosis factor-α (TNF-α), soluble TNF receptor-I (sTNFR-I), sTNFR-II, C-reactive protein (CRP), and interleukin-6 (IL-6) were assessed. All MOI and adiposity measures significantly decreased with weight loss. Significant ethnic differences with weight loss were observed for fat mass, body fat, intra-abdominal adipose tissue (IAAT), sTNFR-I, and sTNFR-II. Mixed-model analysis indicated that adjusting for change in IAAT explained ethnic differences in change in TNF-α and the decrease in TNF-α with weight loss, while total fat mass only explained the decrease in sTNFR-I and sTNFR-II with weight loss. In conclusion, all MOI decreased following weight loss among W, whereas only IL-6 and CRP decreased following weight loss in AA. The most distinct phenotypic difference observed was a greater impact of weight loss on TNF-α in W compared to AA, which was directly associated with IAAT in W.

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Available from: Gordon Fisher, Oct 21, 2014
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    • "In mice, a reduction in abdominal adiposity obtained by bariatric surgery was accompanied by an improvement in adipose tissue inflammation [24]. In white women Fisher et al. found that caloric restriction induced weight loss resulted in a greater TNF-α decrease as compared to Afro American women and that this could be explained by a greater loss of intra abdominal adipose tissue as measured by dual-energy X-ray absorptiometry [25]. Our study is the first in which visceral and subcutaneous fat loss are directly compared in terms of association with changes in adipokynes profile. "
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    PLoS ONE 12/2012; 7(12):e52774. DOI:10.1371/journal.pone.0052774 · 3.23 Impact Factor
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    • "However to date, results vary as to whether or not inflammation differs between AA and EA. Khera et al. found higher hs-CRP concentrations among AA men and women between ages 30–65 years as compared to EA [12], whereas we have previously shown no differences in hs-CRP concentrations between AA and EA premenopausal women [13]. Additionally, AA have been shown to have greater arterial stiffness and endothelial dysfunction compared to EA [14] [15] [16]. "
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