Damping by Depletion

Laboratory of Experimental Immunology, WPI Immunology Frontier Research Center, Osaka University, Suita, Japan.
Science (Impact Factor: 33.61). 04/2011; 332(6029):542-3. DOI: 10.1126/science.1206122
Source: PubMed


An immunoregulatory protein removes ligands from antigen-presenting cells, thereby suppressing immune responses.

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    • "The negative effects are mediated, not surprisingly, by two cell surface “receptors” that are expressed extraordinarily highly on Treg cells – IL-2R (CD25) and the CD152 (CTLA-4) receptors. In order to understand the immunosuppressive effect of Tregs in vitro, it is important to distinguish the direct impact on T-cells mediated by IL-2R and indirect inhibitory effects on APC mediated by CTLA-4 (Pandiyan et al., 2007; Sakaguchi and Wing, 2011; Wing et al., 2011). "
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