Article

Macrocyclic chelator assembled RGD multimers for tumor targeting.

Molecular Imaging Program at Stanford, Department of Radiology, Stanford University Medical Center, California 94305, USA.
Bioorganic & medicinal chemistry letters (Impact Factor: 2.65). 06/2011; 21(11):3423-6. DOI: 10.1016/j.bmcl.2011.03.110
Source: PubMed

ABSTRACT Macrocyclic chelators have been extensively used for complexation of metal ions. A widely used chelator, DOTA, has been explored as a molecular platform to assemble multiple bioactive peptides in this paper. The multivalent DOTA-peptide bioconjugates demonstrate promising tumor targeting ability.

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