Article

[Simulation of Drosophila aging in silico].

Advances in gerontology = Uspekhi gerontologii / Rossiĭskai͡a akademii͡a nauk, Gerontologicheskoe obshchestvo 01/2010; 23(4):557-63. pp.557-63
Source: PubMed

ABSTRACT One of the main tasks of modern gerontology is isolation of the group of phenomena essential for aging from epiphenomenona accompanying them. The modern methods of simulation modeling may be the proper tool for correct isolation. The point of their application is reproduction of external aging manifestations in silico, and, in the first place, of standard survival curves with the help of the simplest internal mechanism. Such a mechanism seems to be the prime mover of aging. The aging model of one the most popular objects of experimental biology, a fruit fly Drosophila melanogaster created by us (http://winmobile.biz/moton/moto.html), is based on the assumption that the key mechanism of aging is cellularity loss, the speed of which is determined by the parameters of active oxygen forms generation in motoneurons.

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Keywords

active oxygen forms generation
 
aging model
 
Drosophila melanogaster
 
epiphenomenona accompanying
 
experimental biology
 
main tasks
 
modern gerontology
 
modern methods
 
motoneurons
 
phenomena essential
 
popular objects
 
proper tool