Article

Encapsulation of phthalocyanine supramolecular stacks into virus-like particles.

Laboratory for Biomolecular Nanotechnology, MESA+ Institute, University of Twente, P.O. Box 207, 7500 AE Enschede, The Netherlands.
Journal of the American Chemical Society (impact factor: 9.91). 05/2011; 133(18):6878-81. DOI:10.1021/ja110752u pp.6878-81
Source: PubMed

ABSTRACT We report herein the encapsulation of a water-soluble phthalocyanine (Pc) into virus-like particles (VLPs) of two different sizes, depending on the conditions. At neutral pH, the cooperative encapsulation/templated assembly of the particles induces the formation of Pc stacks instead of Pc dimers, due to an increased confinement concentration. The Pc-containing VLPs may potentially be used as photosensitizer/vehicle systems for biomedical applications such as photodynamic therapy.

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Keywords

biomedical applications
 
different sizes
 
increased confinement concentration
 
neutral pH
 
particles induces
 
Pc dimers
 
Pc stacks
 
Pc-containing VLPs
 
photosensitizer/vehicle systems
 
VLPs
 
water-soluble phthalocyanine