Article

[Preparation and in vitro release characteristics of curcumin in nanosuspensions].

Chongqing Key Laboratory of Biochemistry & Molecular Pharmnacology, School of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 01/2011; 36(2):132-5. pp.132-5
Source: PubMed

ABSTRACT To prepare curcumin albumin nanosuspensions and study its release characteristics in vitro.
Curcumin albumin nanosuspensions were prepared by solvent evaporation method. The nanosuspensions were characterized in terms of morphology, size, encapsulation efficiency and in vitro drug release.
The mean size of albumin nanosuspensions before lyophilization was 245.2 nm and 240.3 nm after reconstitution. The distribution of particle size was uniform. The encapsulation efficiency was (42.39 +/- 0.91)%. In vitro release study revealed that the 72 h accumulative release percentage reached 96%.
The method described to prepare curcumin albumin nanosuspensions is simple. It might be a novel vehicle potentially for nanoparticle drug delivery system of curcumin.

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Keywords

72 h accumulative release percentage
 
albumin nanosuspensions
 
Curcumin albumin nanosuspensions
 
encapsulation efficiency
 
morphology
 
nanoparticle drug delivery system
 
novel vehicle
 
release characteristics
 
solvent evaporation method
 
vitro
 
vitro drug release
 
vitro release study