Article

Maternal HIV/AIDS status and neurological outcomes in neonates: a population-based study.

Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, 13201 Bruce B. Downs Blvd., MDC 56, Tampa, FL 33612, USA.
Maternal and Child Health Journal (impact factor: 2.24). 04/2011; 16(3):641-8. DOI:10.1007/s10995-011-0799-4 pp.641-8
Source: PubMed

ABSTRACT This study sought to examine the association between maternal HIV/AIDS infection and neonatal neurologic conditions in the state of Florida. We analyzed all births in the state of Florida from 1998 to 2007 using hospital discharge data linked to birth certificate records. The main outcomes of interest included selected neonatal neurologic complications, namely: fetal distress, cephalohematoma, intracranial hemorrhage, seizure, feeding difficulties, and other central nervous system complications. The sample size for this study was 1,645,515 records. All forms of substance abuse as well as cesarean section deliveries were more frequent in mothers with HIV/AIDS. Infants born to HIV-infected mothers showed higher proportions of feeding difficulties and seizures whereas HIV-negative mothers had a greater proportion of cases of fetal distress and cephalohematoma. Seizures and feeding difficulties are common among infants born to HIV/AIDS infected mothers. This population-based retrospective cohort study provides further understanding of the association between maternal HIV/AIDS status and neonatal neurological outcomes.

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Keywords

birth certificate records
 
births
 
central nervous system complications
 
cesarean section deliveries
 
difficulties
 
fetal distress
 
forms
 
higher proportions
 
HIV-negative mothers
 
HIV/AIDS
 
hospital discharge data
 
intracranial hemorrhage
 
main outcomes
 
maternal HIV/AIDS infection
 
maternal HIV/AIDS status
 
neonatal neurologic complications
 
neonatal neurologic conditions
 
neonatal neurological outcomes
 
population-based retrospective cohort study
 
substance abuse