[The importance of pharmacogenetic tests in evaluation of the effectiveness of methotrexate treatment in rheumatoid arthritis (part 2)].

Jerzy Swierkot, Ryszard Slęzak

Klinika Reumatologii i Chorób Wewnętrznych we Wrocławiu.

Journal Article: Postępy Higieny i Medycyny Doświadczalnej (Advances in Hygiene and Experimental Medicine) 01/2011; 65:207-15.

Abstract

Much hope is currently associated with individualization of therapy provided to rheumatoid arthritis (RA) patients. The search is underway for biochemical and clinical markers that would be useful in prediction of a good response to methotrexate (MTX) therapy. Along with clinical factors, genetic predisposition may also be helpful. Polymorphism of genes participating in MTX metabolism may affect the drug’s efficacy and the rate of adverse effects. Pharmacogenetic studies may contribute to more effective individualization of therapy for RA patients. The purpose of the study was to determine the significance of gene polymorphisms MTHFR C677T and A1298C for efficacy of MTX therapy in RA patients. Patients possessing determined polymorphisms should be particularly carefully evaluated because of a higher risk of occurrence of adverse effects.

Source: PubMed

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Keywords

adverse effects
 
clinical factors
 
clinical markers
 
drug’s efficacy
 
effective individualization
 
gene polymorphisms MTHFR C677T
 
genes
 
genetic predisposition
 
good response
 
individualization
 
MTX
 
MTX metabolism
 
MTX therapy
 
Patients
 
Pharmacogenetic studies
 
Polymorphism
 
polymorphisms
 
RA patients