Article

Enamine catalysis.

Department of Chemistry, University of Jyväskylä, P. O. B. 35, FI-40014 JYU, Jyväskylä, Finland.
Topics in current chemistry (impact factor: 4.29). 01/2010; 291:29-75. DOI:10.1007/978-3-642-02815-1_21 pp.29-75
Source: PubMed

ABSTRACT The reversible reaction of primary or secondary amines with enolizable aldehydes or ketones affords nucleophilic intermediates, enamines. With chiral amines, catalytic enantioselective reactions via enamine intermediates become possible. In this review, structure-activity relationships and the scope as well as current limitations of enamine catalysis are discussed.

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Keywords

catalytic enantioselective reactions
 
chiral amines
 
enamine catalysis
 
enamine intermediates
 
enamines
 
ketones affords nucleophilic intermediates
 
reversible reaction
 
secondary amines
 
structure-activity relationships