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Mitochondrial regulation of cell death in the Drosophila ovary

Department of Biology, Boston University, Boston, MA, USA.
Autophagy (Impact Factor: 11.42). 07/2011; 7(7):793-4. DOI: 10.4161/auto.7.7.15695
Source: PubMed

ABSTRACT Interactions between the Bcl-2 family proteins and the mitochondrial fission and fusion machinery regulate cell death in mammals and worms. In Drosophila, the Bcl-2 family proteins have not been shown to be major regulators of cell death. However, emerging evidence suggests that mitochondrial remodeling may be important in Drosophila cell death. We recently demonstrated a series of events that occur during follicle removal in the Drosophila ovary that included mitochondrial remodeling and clustering, followed by uptake and degradation in the follicle cells. Importantly, the Bcl-2 family proteins, mitochondrial dynamics, and autophagic proteins regulate these events.

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