Hypolipidemic effect of fresh Triticum aestivum (wheat) grass juice in hypercholesterolemic rats. Acta Pol Pharm

Department of Pharmacology, Gajara Raja Medical College, Gwalior, M.P., India.
Acta poloniae pharmaceutica (Impact Factor: 0.74). 01/2011; 68(2):291-4.
Source: PubMed


Present study was aimed to elucidate hypolipidemic effect of fresh Triticum aestivum (common wheat) grass juice (GJ) in experimentally induced hypercholesterolemia in rats and to investigate its role in cholesterol excretion. Hypercholesterolemia was induced experimentally in rats by including 0.75 g% cholesterol and 1.5 g% bile salts in normal diet for 14 days. Hypercholesterolemic rats were administered fresh Triticum aestivum GJ at the dose of 5 mL/kg and 10 mL/kg and the standard drug atorvastatin 0.02% w/v in 2% gum acacia suspension at the dose of 1 mg/kg for 14 days by gavage. Blood samples were collected after 24 h of last administration and used for estimation of lipid profile. Fecal cholesterol levels were estimated using standard methods. Fresh GJ administration at 5 mL/kg and 10 mL/kg resulted in dose dependent significant decline in total cholesterol (TC), triglycerides (TG), low density lipoprotein-cholesterol (LDL-C) and very low density lipoprotein-cholesterol (VLDL-C) levels in hypercholesterolemic rats. Further, in comparison to atorvastatin, GJ administration at the dose of 10 mL/kg resulted in comparable decrease of TC, LDL-C, TG and VLDL-C levels (p > 0.05). Fecal cholesterol excretion was significantly (p < 0.05) enhanced by Triticum aestivum GJ administration. Phytochemical analysis revealed the presence of flavonoids, triterpenoids, anthraquinol, alkaloids, tannins, saponins and sterols in fresh wheat grass juice. The results of present study revealed hypolipidemic effect of Triticum aestivum GJ in hypercholesterolemic rats by increasing fecal cholesterol excretion. Fresh GJ could have potentially beneficial effect in atherosclerosis associated with hyperlipidemia.

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    ABSTRACT: Triticum aestivum which refers to the young grass of the common wheat plant has become extremely popular in treating a variety of health conditions. In this study we have investigated the mmunomodulatory activity of Triticum aestivum water extract in Swiss albino mice and its effect >n Thl/Th2 cytokine production by spleen cells. Female Swiss albino mice were challenged with 3heep Red Blood Cells (SRBC) and treated with either Triticum aestivum 540 mg kg -1 or prednisolone 5 mg kg -1 body weight for 15 days. Blood was collected from retroorbital plexus to)erform hematological, serological and bone marrow cellularity evaluation. Thl/Th2 cytokines and he p65 subunit of the nuclear factor kappa B (NFkB) were estimated in the splenocytes by ELISA rom supernatants of splenocyte culture. Antioxidant activity of Triticum aestivum was assessed)y using DPPH (2,2'-diphenyl-l-picrylhydrazyl) Assay. Water extract of Triticum aestivum was bund to increase White Blood Cells (WBC), Red Blood Cells (RBC) and Hemoglobin (Hb):oncentration in both normal and myelosuppressed Swiss albino mice. Furthermore, there was iignificant increase in bone marrow cellularity and hemagglutinin (antibody to SRBC) titer in mimals treated with Triticum aestivum compared to control group. Triticum aestivum water extract upregulated Thl cytokines (TNF-α, IL-2 and IFN- γ) and Th2 cytokine (IL4). In contrast, IL-1β (a Thl cytokine) and P65 subunit of NFkB were suppressed in groups treated with Triticum lestivum. Moreover, Triticum aestivum extract restored Prednisolone suppressed TNF--α and IL-2:ytokines. Triticum aestivum appears to have a significant role in immunity and our findings:onfirm its beneficial role in hemoglobin concentration. Furthermore, the results on Th response iuggest a potential role for Triticum aestivum in Thl modulation and thus it's potential role, as a:andidate drug for inflammatory disorders including cancer management should be explored.
    01/2012; 2(1):19-29. DOI:10.3923/ajbmb.2012.19.29
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    ABSTRACT: Pharmacological and biochemical studies on the Ammi majus seeds L. (family Umbelliferae) grown in Egypt are limited. Furocoumarins are the major constituents in the plant seeds. In the present study, the evaluation of the antihyperlipidemic, anti-inflammatory, analgesic, and antipyretic activities on albino rats and mice was done. After 2 months of administration, both the doses (50 and 100 mg/kg body weight [bwt], respectively) of the alcoholic extract of the A. majus seed result in a significant decrease in the concentrations of cholesterol, triglycerides, and low-density lipoprotein and increase in the concentration of high-density lipoprotein. The extract was found to inhibit the rat paw edema at both the doses, which means that it exerts a significant anti-inflammatory activity compared with control-untreated groups at the intervals of 30 and 60 minutes posttreatment. The antipyretic effect of the extract was quite obvious; it showed that 100 mg/kg bwt was more potent in lowering body temperature starting after 1 hour of treatment than the lower dose (50 mg/kg bwt). It is worth to mention that the A. majus extract with its coumarin contents as well as the tested biological activities of the plant was investigated for the first time in the current study. In conclusion, ethanolic extract of the A. majus seeds had antihyperlipidemic, anti-inflammatory, analgesic, and antipyretic activities that are dose dependant.
    International Journal of Toxicology 05/2012; 31(3):294-300. DOI:10.1177/1091581812440889 · 1.29 Impact Factor

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