Article

Nonleukemic myeloid sarcoma of the liver: a case report and review of literature.

Department of Infectious Diseases, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China.
Hepatology International (impact factor: 2.64). 06/2011; 5(2):747-50. DOI:10.1007/s12072-010-9233-z pp.747-50
Source: PubMed

ABSTRACT Myeloid sarcoma (MS) is a neoplasm of immature granulocytes, monocytes, or both involving extramedullary sites. MS with no evidence of leukemia (nonleukemic MS) is very rare and the initial diagnosis can be difficult. This report describes an unusual case of nonleukemic MS of the liver in a 16-year-old patient presenting as debilitating hepatomegaly. A liver biopsy revealed diffuse infiltration by neoplastic cells of myeloid lineage (CD68, myeloperoxidase). A bone marrow biopsy showed no evidence of medullary involvement. The patient subsequently developed heart failure. Autopsy revealed infiltration of most organs by neoplastic cells but failed to identify abnormal myeloid cells in bone marrow.

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Keywords

16-year-old patient
 
abnormal myeloid cells
 
Autopsy
 
bone marrow
 
bone marrow biopsy
 
debilitating hepatomegaly
 
extramedullary sites
 
immature granulocytes
 
liver biopsy
 
medullary involvement
 
myeloid lineage
 
Myeloid sarcoma
 
neoplastic cells
 
nonleukemic MS
 
organs
 
unusual case
 

Xiao Feng Hang