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Cinnamon Intake Lowers Fasting Blood Glucose: Meta-Analysis

Department of Nutrition, University of California-Davis, Davis, California 95616, USA.
Journal of medicinal food (Impact Factor: 1.7). 04/2011; 14(9):884-9. DOI: 10.1089/jmf.2010.0180
Source: PubMed

ABSTRACT Cinnamon, the dry bark and twig of Cinnamomum spp., is a rich botanical source of polyphenolics that has been used for centuries in Chinese medicine and has been shown to affect blood glucose and insulin signaling. Cinnamon's effects on blood glucose have been the subject of many clinical and animal studies; however, the issue of cinnamon intake's effect on fasting blood glucose (FBG) in people with type 2 diabetes and/or prediabetes still remains unclear. A meta-analysis of clinical studies of the effect of cinnamon intake on people with type 2 diabetes and/or prediabetes that included three new clinical trials along with five trials used in previous meta-analyses was done to assess cinnamon's effectiveness in lowering FBG. The eight clinical studies were identified using a literature search (Pub Med and Biosis through May 2010) of randomized, placebo-controlled trials reporting data on cinnamon and/or cinnamon extract and FBG. Comprehensive Meta-Analysis (Biostat Inc., Englewood, NJ, USA) was performed on the identified data for both cinnamon and cinnamon extract intake using a random-effects model that determined the standardized mean difference ([i.e., Change 1(control) - Change 2(cinnamon)] divided by the pooled SD of the post scores). Cinnamon intake, either as whole cinnamon or as cinnamon extract, results in a statistically significant lowering in FBG (-0.49±0.2 mmol/L; n=8, P=.025) and intake of cinnamon extract only also lowered FBG (-0.48 mmol/L±0.17; n=5, P=.008). Thus cinnamon extract and/or cinnamon improves FBG in people with type 2 diabetes or prediabetes.

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    • "Incubation of blueberry-DSF at 4, 25 and 37 °C for 22 weeks showed no change in concentration of total polyphenols extracted from the matrix (Roopchand et al., 2012). Assessment of randomised, placebo controlled clinical trials with aqueous cinnamon extracts that measured FBG, showed significant effects on lowering FBG (Davis & Yokoyama, 2011). The use of an aqueous extract may provide a higher dose and/or increased bioavailability of bioactive components. "
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    • "This suggests that perturbed glucose/insulin metabolism may be directly or indirectly involved, at least to some extent, in some forms of hypertension. Furthermore, recent meta-analysis also demonstrated that cinnamon intake lowers FPG [18] [19]. We have already demonstrated the effect of cinnamon and its cellular mechanism on blood glucose and BP regulation in patients with T2DM [6] [20]. "
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    ABSTRACT: Objective: To systematically review and evaluate the effect of short term administration of cinnamon on blood pressure regulation in pre and type 2 diabetes patients by performing a meta-analysis of randomized placebo-controlled clinical trials. Research Methods and Procedures: Medical literature for randomized controlled trials (RCTs) of the effect of cinnamon on blood pressure was systematically searched; 3 original articles published from January 2000 to September 2012 were identified from the MEDLINE database and a hand search of the reference lists of the articles obtained through MEDLINE. The search terms included cinnamon or blood pressure or systolic blood pressure (SBP) or diastolic blood pressure (DBP) or diabetes. A random effects model was used to calculate weighted mean difference and 95% confidence intervals (CI). Results: The pooled estimate of the effect of cinnamon intake on systolic and diastolic blood pressure demonstrated that the use of cinnamon significantly decreased SBP and DBP by 5.39 mmHg (95% CI: -6.89, -3.89) and 2.6 mmHg (95% CI: - 4.53, -0.66) respectively. Conclusion: Consumption of cinnamon (short term) is associated with notable reduction of SBP and DBP. Although cinnamon shows hopeful effects on blood pressure lowering potential, it would be premature to recommend cinnamon for blood pressure control, because of the limited number of studies available. Thus, undoubtedly a long term, adequately powered RCTs involving a larger number of patients is needed to appraise the clinical potential of cinnamon on blood pressure control among patients with type 2 diabetes mellitus. Key words: Blood pressure, Diabetes, Cinnamon, Blood glucose, randomized control trials.
    Nutrition 05/2013; · 3.05 Impact Factor
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    • "However, meta-analysis of cinnamon clinical studies 60 limited to randomized, placebo controlled trials that measured fasting blood glucose (FBG), showed overall significant effects on lowering FBG (Davis & Yokoyama, 2011). Furthermore, 62 evaluation of human trials that used only aqueous cinnamon extracts showed a greater level of significance for lowering blood glucose (Davis & Yokoyama, 2011). Thus, the form in which 64 cinnamon is administered may be important since extracts (aqueous and/or organic solvent extraction) and powders (pulverized bark material) would provide different compositions of 66 phytochemicals with different levels of bioavailability. "
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    ABSTRACT: Cinnamon has a long history of medicinal use and continues to be valued for its therapeutic potential for improving metabolic disorders such as type 2 diabetes. In this study, a phytochemically-enhanced functional food ingredient that captures water soluble polyphenols from aqueous cinnamon extract (CE) onto a protein rich matrix was developed. CE and cinnamon polyphenol-enriched defatted soy flour (CDSF) were effective in acutely lowering fasting blood glucose levels in diet induced obese hyperglycemic mice at 300 and 600mg/kg, respectively. To determine mechanisms of action, rat hepatoma cells were treated with CE and eluates of CDSF at a range of 1-25μg/ml. CE and eluates of CDSF demonstrated dose-dependent inhibition of hepatic glucose production with significant levels of inhibition at 25μg/ml. Furthermore, CE decreased the gene expression of two major regulators of hepatic gluconeogenesis, phosphoenolpyruvate carboxykinase and glucose-6-phosphatase. The hypoglycemic and insulin-like effects of CE and CDSF may help to ameliorate type 2 diabetes conditions.
    Food Chemistry 12/2012; 135(4):2994-3002. DOI:10.1016/j.foodchem.2012.06.117 · 3.26 Impact Factor
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