Fibromyalgia and obesity: the hidden link

Rheumatology Research Unit, Clinical and Experimental Medicine Department, University of Catanzaro "Magna Graecia", University Campus "Salvatore Venuta", Viale Europa, Catanzaro, Italy.
Rheumatology International (Impact Factor: 1.63). 04/2011; 31(11):1403-8. DOI: 10.1007/s00296-011-1885-z
Source: PubMed

ABSTRACT Fibromyalgia is a chronic disorder of uncertain etiology, characterized by widespread pain, muscle tenderness, and decreased pain threshold to pressure and other stimuli. Obesity is a well-known aggravating factor for certain rheumatologic conditions, such as knee osteoarthritis. Emerging evidences are exploring the link between obesity and other rheumatic diseases, such as fibromyalgia. Epidemiological data show that fibromyalgia patients have higher prevalence of obesity (40%) and overweight (30%) in multiple studies compared with healthy patients. Several mechanisms have been proposed to explain "the hidden link", but at this time is not possible to ascertain whether obesity is cause or consequence of fibromyalgia. Among mechanisms proposed, there are the following: impaired physical activity, cognitive and sleep disturbances, psychiatric comorbidity and depression, dysfunction of thyroid gland, dysfunction of the GH/IGF-1 axis, impairment of the endogenous opioid system. In this article, we review the scientific evidence supporting a possible link between obesity and fibromyalgia, how obesity influences fibromyalgia symptoms and how fibromyalgia severity can be improved by weight loss. In addition, we analyze the possible mechanisms by which fibromyalgia and obesity interrelate.


Available from: Rosa Daniela Grembiale, Sep 23, 2014
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The objective of this study was to evaluate the problem of multiple chronic conditions and polypharmacy in patients with fibromyalgia. Retrospective medical record review. Olmsted County, Minnesota. 1111 adults with fibromyalgia. Number and type of chronic medical and psychiatric conditions, medication use. Medical record review demonstrated that greater than 50% of the sample had seven or more chronic conditions. Chronic joint pain/degenerative arthritis was the most frequent comorbidity (88.7%), followed by depression (75.1%), migraines/chronic headaches (62.4%) and anxiety (56.5%). Approximately, 40% of patients were taking three or more medications for symptoms of fibromyalgia. Sleep aids were the most commonly prescribed medications in our sample (33.3%) followed by selective serotonin reuptake inhibitors (28.7%), opioids (22.4%) and serotonin norepinephrine reuptake inhibitors (21.0%). The results of our study highlight the problem of multiple chronic conditions and high prevalence of polypharmacy in fibromyalgia. Clinicians who care for patients with fibromyalgia should take into consideration the presence of multiple chronic conditions when recommending medications. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to
    BMJ Open 01/2015; 5(3):e006681. DOI:10.1136/bmjopen-2014-006681 · 2.06 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Objetivos Avaliar a composição corporal de mulheres com fibromialgia (FM) em relação ao valor de referência para mulheres saudáveis. Pacientes e Métodos Estudo transversal observacional, composto por 52 mulheres diagnosticadas com fibromialgia conforme os critérios do American College of Rheumatology (ACR, 1990), selecionadas no Ambulatório de Fibromialgia do Hospital de Clínicas da Universida-de Federal do Paraná (HC-UFPR). As pacientes voluntárias foram divididas em dois grupos, 28 pacientes com Índice de Massa Corporal (IMC) igual ou superior (≥) a 25 kg/m2, e 24 pacientes com IMC igual ou inferior (≤) a 24,99 kg/m2 e submetidas ao exame físico para a contagem dos tender points (TP), além de preencherem o questionário de impacto da fibromialgia (FIQ). A avaliação da composição corporal foi realizada por meio da Absorciometria Radiológica de Dupla Energia (DXA). Os valores do percentual de massa gorda (% de MG), encontrados nos dois grupos, foram comparados ao percentual médio de MG por idade e sexo, descrito por Heward (2004). Resultados A idade média dos grupos pesquisados foi de 47,8 ± 8,6 anos, o score do FIQ foi de 70,5 ± 18,6 e TP 16,2 ± 2,0. O IMC médio foi de 26,4 ± 4,1 kg/m2, e a quantidade de MG foi de 25,2 ± 7,8 kg ou 39,5% ± 6,8%, e de massa magra (MM) foi de 37,2 ± 3,7 kg ou 60,4% ± 7,3%. No grupo com IMC ≤ 25 kg/m2 o percentual de MG foi de 33,8% (21,5 – 42,4), e no grupo com IMC ≥ 25 kg/m2 o percentual de MG foi de 44,4% (37,6 – 56,2). Conclusão Tanto mulheres com FM eutróficas quanto as com sobrepeso e obesas apresentaram percentual de MG acima dos valores de referência de mulheres saudáveis.
    08/2014; 54(4):273–278. DOI:10.1016/j.rbre.2014.03.024
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Bu derlemenin amacı, egzersizin sağlık yararları hakkında güncel bilgileri gözden geçirmektir. Rehabilitasyon hekimliğinde, ayrıntılı reçetelendirilmiş egzersiz programı en önemli modalitedir. Bu yazıda, egzersizin özellikle kardiyovasküler hastalıklar, depresyon, demans, obezite ve günlük pratiğimizde sıklıkla görülen kronik ağrı sendromları üzerine olan sağlık yararları üzerinde durulmuştur. Egzersizin bu hastalıkların önlenmesi ve tedavisindeki önemli rolü incelenip, egzersiz önerileri derlenmiştir.The purpose of this review is to provide current information concerning the health benefits of exercise. In rehabilitation medicine, a detailed prescription of the exercise program is the most important modality. In this paper, the health benefits of exercise, especially on the cardiovascular diseases, depression, dementia, obesity, and chronic pain syndrome, frequently seen in our daily practice, are emphasized. The role of exercise in the prevention and treatment of these diseases is examined, and the recommendations for exercise are reviewed.
    FTR - Turkiye Fiziksel Tip ve Rehabilitasyon Dergisi 10/2014; 60(Supp 2):9-14. DOI:10.5152/tftrd.2014.33716 · 0.08 Impact Factor