Metal ions affecting reproduction and development. Met Ions Life Sci 8:263-303

Department of Experimental and Applied Medicine, Unit of Occupational Medicine and Industrial Hygiene, University of Brescia, P. le Spedali Civili, 1, I-25123 Brescia, Italy.
Metal ions in life sciences 01/2011; 8(1):263-303.
Source: PubMed


Many metal ions (lead, mercury, arsenic, cadmium, chromium, nickel, vanadium, copper, lithium) exert a wide variety of adverse effects on reproduction and development, including influence on male and female subfertility or fertility, abortions, malformations, birth defects, and effects on the central nervous system. The effects produced by metal ions depend on several factors, such as timing and duration of exposure, their distribution and accumulation in various organs (e.g., the nervous system), and on the interference with specific developmental processes. Neonatal and early postnatal periods are lifespan segments during which sensitivity to metals is high; e.g., lead toxicity on the developing organism is paradigmatic of related well known and still open questions. In more recent decades, important mechanisms of action have been suggested: the endocrine disruption via impact of metal ions on reproductive hormones and the oxidative stress. While experimental data provide clear evidence of effects of many metals, human data are scant and traditionally limited to high levels of a few metal ions, like lead on male fertility. Less documented are reproductive effects for mercury, manganese, chromium, nickel, and arsenic for the same gender. More complex is the demonstration of effects on female reproduction and on pregnancy. The action of lead, arsenic, cadmium, chromium, and mercury may in fact be relevant in several stages, beginning in fetal life, during early development or maturity, and is characterized by subfertility, infertility, intrauterine growth retardation, spontaneous abortions, malformations, birth defects, postnatal death, learning and behavior deficits, and premature aging. Also, for females the evidences of specific aspects such as fertility or abortions are usually higher and clearer from animal experiments than from human studies.

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    • "Exposure during neurulation results in the formation of neural tube defects in all species, the extent of which depends on dose, time of exposure, strain, and nutritional status [12, 14–16]. Other effects include male and female subfertility or abortions [17, 18]. Moreover, Kippler et al. [19] reported that maternal exposure to Cd was significantly and inversely associated with the head circumference and birth weight of girls. "
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    • "Uranium , mercury and lead , ( lg / kg , mean ± SD ) in hair samples from parents from Italy , Iran , and Fallujah Iraq Bull Environ Contam Toxicol exposure can culminate in birth deformities by increasing oxidative stress in the womb as the fetus grows ( Apostoli and Catalani 2011 ) . "
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    • "[5] [6] [7] Besides these toxic effects, also the reproductive toxicity of nickel is described in the literature, however, no studies were located regarding reproductive effects in humans after oral exposure to nickel. [3] [8] [9] [10] [11] Apostoli and Catalani [12] have stated that experimental data provide clear evidence of reproductive effects of many metals, but human data are scant and traditionally limited to high levels of a few metal ions, like lead on male fertility. Less documented are reproductive effects for mercury, manganese, chromium, Fig. 1. "
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