No association between coffee, tea or caffeine consumption and breast cancer risk in a prospective cohort study

INSERM (Institut National de la Santé et de la Recherche Médicale), Center for Research in Epidemiology and Population Health (CESP), U1018, 114 rue Edouard Vaillant, F-94805 Villejuif, France.
Public Health Nutrition (Impact Factor: 2.68). 04/2011; 14(7):1315-20. DOI: 10.1017/S1368980011000371
Source: PubMed


Numerous mechanisms for the effects of coffee, tea and caffeine on the risk of breast cancer have been suggested. Caffeine intake has already been associated with high plasma levels of female hormones, but associations have not been clearly demonstrated in epidemiological studies.
We examined prospectively the association of coffee, tea and caffeine consumption with breast cancer risk in a French cohort study.
Dietary information was obtained from a 208-item diet history questionnaire self-administered in 1993-1995. Multivariable Cox proportional hazards regression models were used to estimate hazards ratios and 95 % confidence intervals.
The study was conducted on 67 703 women with available dietary information. During a median follow-up of 11 years, 2868 breast cancer cases were diagnosed.
Median intake was 280 ml/d (2·2 cups/d) for coffee and 214 ml/d (1·7 cups/d) for tea. Median caffeine intake was 164 mg/d. No association was found between consumption of coffee, tea or caffeine and breast cancer risk. Sub-analyses by tumour receptor status, menopausal status, type of coffee (regular or decaffeinated) and meals at which beverages were drunk led to the same conclusion.
Results from this prospective study showed no relationship between coffee, tea or caffeine intake and breast cancer risk overall or by hormone receptor status.

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    • "Breast Cancer Fagherazzi et al. 2011 [57] "
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    ABSTRACT: We conducted a dose-response meta-analysis of prospective studies to summarize evidence of the association between tea consumption and the risk of breast, colorectal, liver, prostate, and stomach cancer. We searched PubMed and two other databases. Prospective studies that reported risk ratios (RRs) with 95% confidence intervals (CIs) of cancer risk for >=3 categories of tea consumption were included. We estimated an overall RR with 95% CI for an increase of three cups/day of tea consumption, and, usingrestricted cubic splines, we examined a nonlinear association between tea consumption and cancer risk. Forty-one prospective studies, with a total of 3,027,702 participants and 49,103 cancer cases, were included. From the pooled overall RRs, no inverse association between tea consumption and risk of five major cancers was observed. However, subgroup analysis showed that increase in consumption of three cups of black tea per day was a significant risk factor for breast cancer (RR, 1.18; 95% CI, 1.05-1.32). Ourresults did not show a protective role of tea in five major cancers. Additional large prospective cohort studies are needed to make a convincing case for associations.
    BMC Cancer 03/2014; 14(1):197. DOI:10.1186/1471-2407-14-197 · 3.36 Impact Factor
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    • "I 2 = 0.00%). Data from 19 studies (Harris et al. 2012; Fagherazzi et al. 2011; Boggs et al. 2010; Bhoo Pathy et al. 2010; Larsson et al. 2009; Ganmaa et al. 2008; Hirvonen et al. 2006; Adebamowo et al. 2005; Kumar et al. 2009; Baker et al. 2006; Wu et al. 2003; Key et al. 1999; Michels et al. 2002; Zheng et al. 1996; Goldbohm et al. 1996; Ewertz & Gill 1990; Schairer et al. 1987; Lubin et al. 1985; Rosenberg et al. 1985 "
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    ABSTRACT: Previous meta-analysis indicated conflicting results in case-control versus cohort studies on the association of green tea with breast cancer risk, and conflicting results were also found in case-control versus cohort studies in another meta-analysis on the association of black tea with breast cancer risk. Many studies were published after the previous meta-analysis. Besides, the dose-response relationship of tea consumption with breast cancer risk is unclear. Thus the association of tea consumption with breast cancer risk was assessed incorporating new publications. Summary relative risk (RR) for highest versus lowest level of tea consumption was calculated based on fixed or random effect models. Dose-response relationship was assessed by restricted cubic spline model and multivariate random-effect meta-regression. The combined results from 9 studies suggested no significant association between green tea consumption and breast cancer risk (RR = 0.82, 95% CI = 0.64-1.04). No significant association was found among cohort studies and case-control studies after sensitivity analysis, respectively. A linear but not significant dose-response association was found between green tea consumption and breast cancer risk. The combined results from 25 studies demonstrated no significant association between black tea consumption and breast cancer risk (RR = 0.98, 95% CI = 0.93-1.03), and no significant association was found in subgroup analysis. A linear but not significant dose-response association was found between black tea consumption and breast cancer risk. Based on the current evidence, black tea and green tea might not contribute significantly to breast cancer risk, respectively.
    SpringerPlus 12/2013; 2(1):240. DOI:10.1186/2193-1801-2-240
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    • "23 studies were included for the dose–response analysis of coffee intake and risk of breast cancer [9]–[16], [24]–[38]. The pooled RR for a 2 cups per day increment in coffee intake was 0.98 (95%CI 0.97–1.00) "
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    ABSTRACT: This updated meta-analysis was conducted to assess the association between coffee consumption and breast cancer risk. We conducted a systematic search updated July 2012 to identify observational studies providing quantitative estimates for breast cancer risk in relation to coffee consumption. Pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated using a random-effects model, and generalized least square trend estimation was used to assess dose-response relationships. A total of 26 studies (16 cohort and 10 case-control studies) on coffee intake with 49497 breast cancer cases were included in the meta-analysis. The pooled RR showed a borderline significant influence of highest coffee consumption (RR = 0.96; 95% CI 0.93-1.00), low-to moderate coffee consumption (RR = 0.99; 95% CI 0.95-1.04), or an increment of 2 cups/day of coffee consumption (RR = 0.98; 95% CI 0.97-1.00) on the risk of breast cancer. In stratified analysis, a significant inverse association was observed in ER-negative subgroup. However, no significant association was noted in the others. Our findings suggest that increased coffee intake is not associated with a significantly reduced risk of breast cancer, but we observe an inverse association in ER-negative subgroup analysis. More large studies are needed to determine subgroups to obtain more valuable data on coffee drinking and breast cancer risk.
    PLoS ONE 01/2013; 8(1):e52681. DOI:10.1371/journal.pone.0052681 · 3.23 Impact Factor
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