Article

Do cilia put brakes on the cell cycle?

Genentech Inc, 1 DNA way, MC214, South San Francisco, California 94080, USA.
Nature Cell Biology (Impact Factor: 20.06). 04/2011; 13(4):340-2. DOI: 10.1038/ncb0411-340
Source: PubMed

ABSTRACT Two papers in this issue show that dynein-binding proteins may regulate the G1-S transition through an effect on cilia. Nde1, a known partner of dynein light chain LC8, controls ciliary length in vitro and in zebrafish, and influences the G1-S progression. The phosphorylation of Tctex1, a dynein light chain, modulates cilia length and accelerates G1-S, thereby regulating proliferation-differentiation decisions in the developing mouse neocortex.

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