Article

Thrombocytopenia in infants and children.

Thomas Jefferson University, Philadelphia, PA, USA.
Pediatrics in Review (Impact Factor: 0.82). 04/2011; 32(4):135-49; quiz 150-1. DOI: 10.1542/pir.32-4-135
Source: PubMed
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    ABSTRACT: Background In this study, the effects of viral infections on platelet (PLT) count have been reported. This study examined the correlation between PLT count and respiratory virus (RV) infections.Methods Patients who visited Dankook University Hospital between December 2006 and February 2014 with symptoms of suspected RV infection were recruited. Multiplex reverse transcriptase polymerase chain reactions identified the causative virus(es). PLT counts were analyzed with respect to virus, age and sex of the patient, and length of hospital stay.ResultsOf the 8,147 patients, 62.8% were RV-positive, and 18.6% of RV-positive patients had abnormal PLT counts. There were no differences in the rates of abnormal PLT counts between single-infection and virus co-infection cases. In RV infection patients, the incidence of abnormal PLT count increased with age and varied depending on the RV infection type. Patients with abnormal PLT count stayed in hospital longer than those with normal PLT count.Conclusions The incidence of thrombocytopenia was higher among the elderly; in younger patients, thrombocytosis was more prevalent than thrombocytopenia. Respiratory tract infections caused by different viruses resulted in varied PLT count changes. Further systematic research of PLT count changes related to viral infections is required.
    Journal of Clinical Laboratory Analysis 12/2014; DOI:10.1002/jcla.21822 · 1.14 Impact Factor
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    ABSTRACT: Objective: Cytopenia is a common hematologic complication of viral infections. However, information regarding hematologic effects of common respiratory virus infections is scarce. This study aimed to evaluate hematologic complications and the clinical course of patients infected with common respiratory viruses. Methods: We retrospectively analyzed 496 patients with respiratory tract infections admitted to the Department of Pediatrics, Wonkwang University Hospital from November 2011 to March 2012 using multiplex real-time polymerase chain reaction to detect the presence of respiratory viruses and hematologic abnormalities. Results: Respiratory viruses were identified in 379 patients. Respiratory syncytial virus (RSV) was most frequently detected (55.7%), followed by influenza A (Flu-A, 23.0%). Further, cytopenia was observed in 35.5% of RSV-infected patients, 25.0% of Flu-A-infected patients, and 34% of patients infected by other viruses. Each virus caused a decrease in 3 blood cell component values, which corresponded with cytopenia frequency. Of the 379 infected patients, 83 had anemia (); 46 had neutropenia (); and 23 had transient thrombocytopenia (). However, no patient required treatment. A comparison of clinical characteristics between RSV- and Flu-A-positive patients with anemia revealed that RSV-infected patients had significantly longer duration of hospitalization. RSV was detected more commonly in young neutropenic patients, who had a shorter duration of fever. Conclusions: Our findings suggest that infections, particularly RSV and Flu-A, result in varying degrees of cytopenia, which usually improves without treatment and does not affect the clinical course of the infection.
    01/2013; 20(3).
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    ABSTRACT: Background. Platelet-derived indices have a well-established correlation with the differential diagnosis of thrombocytopenia in adult-based research. These indices include mean platelet volume, platelet distribution width, and platelet-large cell ratio. Objective. To determine the values of platelet-derived indices in a pediatric population with diagnoses of thrombocytopenia and their etiologic correlation. Materials and methods. Analytic observational diagnostic- test study. The population for this analytical study was pediatric patients between 6 months and 18 years of age who had thrombocytopenia (<100x109/L). The study period was 18 months long. Results. Of 54 subjects, 18 (33.3%) were diagnosed with idiopathic thrombocytopenic purpura, and 36 (66.7%) were diagnosed with acute leukemia. Mean age was 7.4 years and 6.8 years for immune thrombocytopenic purpura and acute leukemia, respectively. Mean platelet distribution width values for immune thrombocytopenic purpura and acute leukemia were 15.08 fL and 10.73, respectively. Mean MPV for immune thrombocytopenic purpura and acute leukemia was 11.7 fL and 9.8 fL, respectively. Mean platelet-large cell ratio was 38.26% and 24.97% for idiopathic thrombocytopenic purpura and acute leukemia, respectively. Differences in these three distinct platelet indices between idiopathic thrombocytopenic purport 􏰆􏰇􏰃􏰀 􏰆􏰘􏰙􏰎􏰉􏰀 􏰍􏰉􏰙􏰚􏰉􏰔􏰅􏰆􏰀 􏰛􏰉􏰄􏰉􏰀 􏰊􏰎􏰆􏰎􏰅􏰊􏰎􏰅􏰘􏰆􏰍􏰍􏰜􏰀 􏰊􏰅􏰝􏰇􏰅􏰞􏰘􏰆􏰇􏰎􏰀 􏰟􏰠􏰡􏰢􏰣􏰢􏰢􏰤􏰣􏰀 The area under the ROC curve for platelet-derived indices 􏰊􏰥􏰏􏰛􏰉􏰃􏰀 􏰎􏰥􏰆􏰎􏰀 􏰎􏰥􏰉􏰜􏰀 􏰛􏰉􏰄􏰉􏰀 􏰆􏰃􏰉􏰦􏰙􏰆􏰎􏰉􏰀 􏰧􏰏􏰄􏰀 􏰃􏰉􏰞􏰇􏰅􏰇􏰝􏰀 􏰎􏰥􏰉􏰀 􏰘􏰆􏰙􏰊􏰉􏰊􏰀 􏰏􏰧􏰀 thrombocytopenia. MPV and platelet-large cell ratio had an area under the curve of 0.89 and 0.88, respectively, while platelet size deviation width had an area under the curve of 0.903. Conclusions. Platelet-derived indices could be useful in the initial approach for the differential diagnosis of pediatric patients with thrombocytopenia.
    Revista de la Facultad de Medicina, Universidad Nacional de Colombia 10/2014; 62(4):547. DOI:10.15446/revfacmed.v62n4.43754

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