High b-Value q-Space Analyzed Diffusion-Weighted MRI Using 1.5 Tesla Clinical Scanner; Determination of Displacement Parameters in the Brains of Normal versus Multiple Sclerosis and Low-Grade Glioma Subjects

Department of Radiology, University of Yamanashi, Chuo-shi, Yamanashi, Japan.
Journal of neuroimaging: official journal of the American Society of Neuroimaging (Impact Factor: 1.73). 03/2011; 22(3):279-84. DOI: 10.1111/j.1552-6569.2011.00596.x
Source: PubMed


We aimed to determine the displacement parameters in the brains of normal individuals relative to brain parenchymal abnormalities, such as multiple sclerosis (MS) and low-grade glioma, by q-space imaging (QSI) using 1.5-T magnetic resonance (MR) scanner.
Thirty-five normal, three pathologically proven low-grade glioma, and five MS subjects were imaged by a 1.5-T MR unit for QSI (b-values, 0-12,000 s/mm(2)). Mean displacement (MD) values in white matter (WM), gray matter (GM), and lateral ventricle (cerebrospinal fluid [CSF]) of normal subjects, plaques, and normal appearing WM (NAWM) of MS subjects and glioma lesions were calculated. Mann-Whitney U test was used for comparison.
In normal subjects, MD values were 6.6 ± 0.2, 8.44 ± 0.41, and 17.08 ± 0.80 μm for WM, GM, and CSF, respectively, while those for NAWM and WM plaques in MS, and glioma lesions were significantly higher at 7.0 ± 0.17, 9.3 ± 2.3, and 9.6 ± 0.40 μm, respectively, compared to WM in normal subjects.
We propose that the relative values of MD obtained by QSI in control and diseased tissues can be useful for diagnosing various WM abnormalities.

Download full-text


Available from: Masaaki Hori, Oct 06, 2015
75 Reads
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Q-space analysis is a new metric that uses multiple, high b-value, diffusion-weighted magnetic resonance (MR) data. This technique shows promising results as a tool to provide information complementary to that of other imaging techniques used on biological tissue in vivo. To investigate the use of a mean displacement (MDP) map of high b-value, q-space imaging (QSI) to characterize spinal and spinal cord lesions in vivo. Eight patients with spine or spinal cord disorders (two neurinomas, one myeloma, three cases of syringohydromyelia, and two cases of cervical spondylosis) were included. The MR imaging protocol consisted of conventional MR sequences, conventional diffusion-weighted imaging (DWI; b = 1000), and high b-value QSI with a maximum q value of 836.9 cm(-1). Apparent diffusion coefficient (ADC) maps of conventional DWI and MDP maps of QSI data were obtained and region-of-interest analyses for the lesions were performed. MDP values of normal spinal cord, cerebrospinal fluid (CSF), and tumor parenchyma were 6.57 ± 0.52, 17.6 ± 2.75, and 8.49 ± 2.09, respectively (µm, mean ± standard deviation). In general, MDP maps were not well correlated with the corresponding ADC maps at the pathologic lesions. Spondylotic lesions tended to have higher MDP values than normal spinal cord, whereas syringohydromyelia produced MDP values slightly lower than those of CSF. The heterogeneous MDP values were probably due to differences in tissues and pathologic structures. This technique has potential to provide additional clinical information to that obtained with conventional MR imaging.
    Acta Radiologica 11/2011; 52(10):1155-8. DOI:10.1258/ar.2011.110226 · 1.60 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: To investigate the use of root mean square displacement (RMSD) and mean diffusional kurtosis (DK) metrics of q-space imaging data to estimate spinal cord compression in patients with early cervical spondylosis. We studied 50 consecutive patients at our institution (22 male, 28 female; mean age 58 years; age range 20-86 years) who had clinical signs and symptoms suggestive of early clinical stage cervical myelopathy. After conventional magnetic resonance (MR) imaging, diffusion tensor and q-space image data were acquired using 3-T MR imaging. Fractional anisotropy (FA), apparent diffusion coefficient (ADC), RMSD and mean DK values were calculated and compared between compressed and uncompressed spinal cords. FA and mean DK values were significantly lower and RMSD was significantly higher (P = 0.0060, 0.0020 and 0.0062, respectively; Mann-Whitney U test with the Bonferroni correction) in compressed spinal cords than in uncompressed cords. ADC was also higher in compressed cords, but this difference was not statistically significant. In the evaluation of spinal cord damage in early cervical spondylosis, mean DK and RMSD values in the spinal cord may be highly sensitive indicators of microstructural change and damage. • Absolute surgical indications for cervical spondylosis with myelopathy remain to be established. • Diffusion tensor MRI shows abnormalities in normal-appearing but compressed spinal cord. • Non-Gaussian diffusion analysis is highly sensitive in revealing spinal cord damage.
    European Radiology 03/2012; 22(8):1797-802. DOI:10.1007/s00330-012-2410-9 · 4.01 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Introduction: To assess and compare age-related diffusion changes in the white matter in different cerebral lobes, as quantified by diffusion-weighted imaging (DWI) and high b-value q-space imaging (QSI). Methods: Seventy-three cases without neurological symptoms or imaging abnormalities were grouped by age as young (<30 years, n = 20), middle-aged (30-49 years, n = 19), old (50-69 years, n = 18), and very old (> 70 years, n = 16) and imaged by a 1.5-T MR scanner for DWI and QSI. Apparent diffusion coefficient (ADC) and mean displacement (MDP) values were calculated in the white matter of frontal, parietal, and temporal lobes and compared using Dunnett's test, with the young group as a control. Results: MDP values in frontal and parietal lobes were significantly higher in old and very old age groups than in the young, while those in the temporal lobes were significantly higher only in the very old group. ADC values were significantly higher in all three lobes in the very old group. Conclusion: QSI is more sensitive than DWI to age-related myelin loss in white matter.
    Neuroradiology 10/2012; 55(3). DOI:10.1007/s00234-012-1099-4 · 2.49 Impact Factor
Show more