Article

Ferruginenes A-C from Rhododendron ferrugineum and their cytotoxic evaluation.

Center of Excellence for Innovation in Chemistry (PERCH-CIC) and Department of Chemistry, Faculty of Science, Mahasarakham University, Maha Sarakham, 44150 Thailand.
Journal of Natural Products (impact factor: 3.13). 03/2011; 74(4):712-7. DOI:10.1021/np100778k pp.712-7
Source: PubMed

ABSTRACT Three new compounds, ferruginenes A (1) and B (2) and a mixture of C-5'(R) and C-5'(S) ferruginene C (3) diastereomers, have been isolated from a cytotoxic chloroform-soluble fraction of the leaves of Rhododendron ferrugineum together with 12 known compounds. The structures of these new compounds were elucidated by analyses of NMR spectroscopic and mass spectrometric data. Compounds 1-3 were tested for their cytotoxicity against three human cancer cell lines, namely, HL-60, HeLa-S3, and MCF-7.

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Keywords

compounds
 
Compounds 1-3
 
cytotoxic chloroform-soluble fraction
 
human cancer cell lines
 
mass spectrometric data
 
new compounds
 
NMR spectroscopic
 
Rhododendron ferrugineum