Contrast-Enhanced Whole-Heart Coronary MRI with Bolus Infusion of Gadobenate Dimeglumine at 1.5 T.

Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA.
Magnetic Resonance Imaging (Impact Factor: 2.09). 02/2011; 66(2):392-398. DOI: 10.1002/mrm.22706
Source: PubMed


We sought to investigate the T(1) kinetics of blood and myocardium after three infusion schemes of gadobenate dimeglumine (Gd-BOPTA) and subsequently compared contrast-enhanced whole-heart coronary MRI after a bolus Gd-BOPTA infusion with nonenhanced coronary MRI at 1.5T. Blood and myocardium T(1) was measured in seven healthy adults, after each underwent three Gd-BOPTA infusion schemes (bolus: 0.2 mmol/kg at 2 ml/sec, hybrid: 0.1 mmol/kg at 2 ml/sec followed by 0.1 mmol/kg at 0.1 ml/sec, and slow: 0.2 mmol/kg at 0.3 ml/sec). Fourteen additional subjects underwent contrast-enhanced coronary MRI with an inversion-recovery steady-state-free-precession sequence after bolus Gd-BOPTA infusion. Images were compared with nonenhanced T(2)-prepared SSFP whole-heart coronary MRI in signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), depicted vessel length, vessel sharpness, and subjective image quality. Bolus and slow infusion schemes resulted in similar T(1) during coronary MRI, whereas the hybrid infusion method yielded higher T(1) values. A bolus infusion of Gd-BOPTA significantly improved SNR, CNR, depicted coronary artery length, and subjective image quality when all segments were collectively compared but not when compared segment by segment. In conclusion, whole-heart SSFP coronary MRI at 1.5T can benefit from a bolus infusion of 0.2 mmol/kg Gd-BOPTA.

Download full-text


Available from: Kraig V Kissinger,
  • [Show abstract] [Hide abstract]
    ABSTRACT: Coronary artery disease (CAD) is the leading cause of death in the adult population in the United States. Imaging is an essential component of the management of CAD, providing both diagnostic and prognostic information. In this review, we will provide an overview of the use of cardiovascular magnetic resonance imaging (CMR) in the evaluation of ischemia in both acute and chronic settings. We will compare CMR to other imaging modalities, highlighting the advantages and opportunities of CMR, as well as limitations.
    PET Clinics 10/2011; 6(4). DOI:10.1016/j.cpet.2011.10.002
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Purpose: To develop an improved chemical shift-based water-fat separation sequence using a water-selective inversion pulse for inversion recovery 3D contrast-enhanced cardiac magnetic resonance imaging (MRI). Materials and Methods: In inversion recovery sequences the fat signal is substantially reduced due to the application of a nonselective inversion pulse. Therefore, for simultaneous visualization of water, fat, and myocardial enhancement in inversion recovery-based sequences such as late gadolinium enhancement imaging, two separate scans are used. To overcome this, the nonselective inversion pulse is replaced with a water-selective inversion pulse. Imaging was performed in phantoms, nine healthy subjects, and nine patients with suspected arrhythmogenic right ventricular cardiomyopathy plus one patient for tumor/mass imaging. In patients, images with conventional turbo-spin echo (TSE) with and without fat saturation were acquired prior to contrast injection for fat assessment. Subjective image scores (1 = poor, 4 = excellent) were used for image assessment. Results: Phantom experiments showed a fat signal-to-noise ratio (SNR) increase between 1.7 to 5.9 times for inversion times of 150 and 300 msec, respectively. The water-selective inversion pulse retains the fat signal in contrast-enhanced cardiac MR, allowing improved visualization of fat in the water-fat separated images of healthy subjects with a score of 3.7 ± 0.6. Patient images acquired with the proposed sequence were scored higher when compared with a TSE sequence (3.5 ± 0.7 vs. 2.2 ± 0.5, P < 0.05). Conclusion: The water-selective inversion pulse retains the fat signal in inversion recovery-based contrast-enhanced cardiac MR, allowing simultaneous visualization of water and fat. J. Magn. Reson. Imaging 2013;37:484–490.
    Journal of Magnetic Resonance Imaging 02/2012; 37(2). DOI:10.1002/jmri.23779 · 3.21 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: We sought to evaluate the efficacy of prospective random undersampling and low-dimensional-structure self-learning and thresholding reconstruction for highly accelerated contrast-enhanced whole-heart coronary MRI. A prospective random undersampling scheme was implemented using phase ordering to minimize artifacts due to gradient switching and was compared to a randomly undersampled acquisition with no profile ordering. This profile-ordering technique was then used to acquire contrast-enhanced whole-heart coronary MRI in 10 healthy subjects with 4-fold acceleration. Reconstructed images and the acquired zero-filled images were compared for depicted vessel length, vessel sharpness, and subjective image quality on a scale of 1 (poor) to 4 (excellent). In a pilot study, contrast-enhanced whole-heart coronary MRI was also acquired in four patients with suspected coronary artery disease with 3-fold acceleration. The undersampled images were reconstructed using low-dimensional-structure self-learning and thresholding, which showed significant improvement over the zero-filled images in both objective and subjective measures, with an overall score of 3.6 ± 0.5. Reconstructed images in patients were all diagnostic. Low-dimensional-structure self-learning and thresholding reconstruction allows contrast-enhanced whole-heart coronary MRI with acceleration as high as 4-fold using clinically available five-channel phased-array coil.
    Magnetic Resonance in Medicine 05/2012; 67(5):1434-43. DOI:10.1002/mrm.24242 · 3.57 Impact Factor
Show more