Article

Magnetic Resonance Imaging in Multiple Sclerosis: The Role of Conventional Imaging

Multiple Sclerosis Program, Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA, 8730 Alden Drive, Thalians E216, Los Angeles, CA 90048, USA.
Neurologic Clinics (Impact Factor: 1.61). 05/2011; 29(2):343-56. DOI: 10.1016/j.ncl.2011.01.005
Source: PubMed

ABSTRACT Magnetic resonance imaging (MRI) of the brain and spinal cord plays a central role in establishing the diagnosis of multiple sclerosis (MS), in monitoring disease activity, and as a key outcome measure in clinical trials of new MS therapies. Conventional MRI continues to evolve, reflecting advances in imaging hardware and software. These advances have led to important new insights into MS disease pathophysiology and can be used to improve patient management. Despite these improvements, standard MRI continues to capture only a small portion of the underlying changes that occur during the course of the disease.

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    • "The MRI can detect changes in inflammatory activity but for quantification of intact myelin and remyelination, magnetization transfer imaging has been proposed. Diffusion tensor imaging can be used to monitor tract-specific changes that may be more closely linked to clinical measures and may be particularly powerful when combined with functional measures, such as functional MRI [10,11]. "
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