A search for overlapping genetic susceptibility loci between non-Hodgkin lymphoma and autoimmune diseases

Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, USA.
Genomics (Impact Factor: 2.28). 03/2011; 98(1):9-14. DOI: 10.1016/j.ygeno.2011.03.007
Source: PubMed


Non-Hodgkin lymphoma (NHL) is a hematological malignancy of the immune system, and, as with autoimmune and inflammatory diseases (ADs), is influenced by genetic variation in the major histocompatibility complex (MHC). Persons with a history of specific ADs also have increased risk of NHL. As the coexistence of ADs and NHL could be caused by factors common to both diseases, here we examined whether some of the associated genetic signals are shared. Overlapping risk loci for NHL subytpes and several ADs were explored using data from genome-wide association studies. Several common genomic regions and susceptibility loci were identified, suggesting a potential shared genetic background. Two independent MHC regions showed the main overlap, with several alleles in the human leukocyte antigen (HLA) class II region exhibiting an opposite risk effect for follicular lymphoma and type I diabetes. These results support continued investigation to further elucidate the relationship between lymphoma and autoimmune diseases.

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    • "Several studies have explored shared genetics among diseases including coeliac disease and other immune diseases [29], non-Hodgkin's lymphoma and autoimmune diseases [30], obesity and asthma [21], and asthma and chronic obstructive pulmonary disease [31]. However, there is very little investigation into population-specific or shared genetic risk factors for a specific disease across different populations. "
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