Article

Hemato-Biochemical Alterations in Cross Bred Cattle Affected with Bovine Theileriosis in Semi Arid Zone

Pakistan Veterinary Journal 01/2011;
Source: DOAJ

ABSTRACT This study was carried out to ascertain the changes in hematology and serum constituents in cross bred cattle affected with bovine theileriosis in semi arid zone of Pakistan. A total of 50 cross bred cows of age 2-5 years were included in the study. Twenty animals of same age were kept as healthy controls. The affected animals showed signs and symptoms of bovine theileriosis i.e., high rise in body temperature, general debility, enlarged prescapular lymph nodes, mucosal hemorrhages, conjunctivitis, etc. These animals were subjected to examination of peripheral blood smears for the presence of Theileria annulata schizonts in infected mononuclear cells and piroplasms in red blood cells. Significant (P≤0.05) decrease was observed in total erythrocyte counts, packed cell volume, hemoglobin, serum total proteins, albumin, globulins, glucose, calcium, phosphorus, cholesterol and triglycerides concentrations in cattle affected with bovine theileriosis compared with healthy controls, while significant (P≤0.05) increase was observed in serum bilirubin and alanine transaminase of affected cattle compared with healthy controls. Non significant differences were observed in serum magnesium and uric acid concentration in both affected and healthy controls. These observations revealed that bovine theileriosis caused by T. annulata in cross bred cattle in semi arid zone is associated with hemato-biochemical alterations.

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    • "Hematological investigation has gained a global popularity as a prime diagnostic and management tool in veterinary practice. It ascertains the physiological, nutritional and pathological status of an organism (Doyle, 2006; Khaliq and Rahman, 2010; Khan et al., 2011) and helps distinguish the normal state from the state of stress, which can be nutritional, physical or environmental (Aderemi, 2004). The dovetailing of many factors such as species, breed, age, sex, nutrition, illness, exercise, transport and seasonal variation affects the haematologic parameters (Farooq et al., 2011). "
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    • "A non-significant decrease in creatinine concentration of the infected group in the present study is to some extent in line with the findings of Omer et al. (2003), who showed a significant decrease in the creatinine concentration in Theileria-infected cattle, but contradicts to the results of Col and Uslu (2007), who showed an increased concentration of blood creatinine during bovine theileriosis. In the present study, the mean values of uric acid showed no significant alteration during sheep theileriosis that is similar to the findings of Khan et al. (2011) in cattle theileriosis. Moreover, the results of Sandhu et al. (1998) "
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    Comparative Clinical Pathology 12/2011; 21(6). DOI:10.1007/s00580-011-1308-2
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    • "The principle for enzymatic determination of urea was measurement of Lglutamate with water and α-ketoglutarate, while that for creatinine determination was to measure the speed of production of colored complex between creatinine and alkaline picrate using spectrophotometer at wavelengths of 340 and 500 nm, respectively. The serum total proteins (STP) were estimated by Biuret method and serum albumin by bromocresol green (BCG) dye binding method (Khan et al., 2011) using spectrophotometer. The serum globulin was calculated by subtracting albumin from STP (Javed et al., 2010). "
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    ABSTRACT: The effects of intra-peritoneal administration of cypermethrin (CY) on biochemistry and histology of liver and kidneys in rabbits were studied. Male rabbits (n = 10 x 4 = 40) in groups B, C and D received low (50 mg.kg-1 body weight), medium (100 mg.kg-1 body weight) and high (150 mg.kg-1 body weight) CY doses, respectively in mustard oil at weekly interval up to day 71. Group A served as control and each animal in this group received equivalent volume of mustard oil. Blood samples without anticoagulant from all animals were collected prior to start of experiment (day 0) and after every treatment, which were used for extraction of serum. The serum was used for analysis of proteins (serum total proteins/STP, serum albumin, serum globulins), aminotransferases (AST & ALT), alkaline phosphatase (ALP), urea and creatinine. Two animals from each group were euthanized fortnightly for histopathological studies. Increases in AST level in sera of CY-treated rabbits were accompanied by histological lesions in liver (different stages of degeneration & bile duct hyperplasia). Increased urea and creatinine concentrations and decreased STP, albumin and globulins in sera of CY-treated rabbits could be due to renal damage. The renal damage appeared histologically in the form of different lesions (pyknotic nuclei, necrosis, sloughed tubular epithelium, cast deposition & increased urinary space) in CY-treated rabbits. It was concluded that cypermethrin at various doses administered during the study produced moderate histological lesions in liver and kidneys along-with biochemical alterations in serum samples. © 2011 Friends Science Publishers
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