Article

Population incidence of Guillain-Barré syndrome: a systematic review and meta-analysis.

Division of High-Consequence Pathogens and Pathology and Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Neuroepidemiology (impact factor: 2.31). 03/2011; 36(2):123-33. DOI:10.1159/000324710
Source: PubMed

ABSTRACT Population incidence of Guillain-Barré syndrome (GBS) is required to assess changes in GBS epidemiology, but published estimates of GBS incidence vary greatly depending on case ascertainment, definitions, and sample size. We performed a meta-analysis of articles on GBS incidence by searching Medline (1966-2009), Embase (1988-2009), Cinahl (1981-2009) and CABI (1973-2009) as well as article bibliographies. We included studies from North America and Europe with at least 20 cases, and used population-based data, subject matter experts to confirm GBS diagnosis, and an accepted GBS case definition. With these data, we fitted a random-effects negative binomial regression model to estimate age-specific GBS incidence. Of 1,683 nonduplicate citations, 16 met the inclusion criteria, which produced 1,643 cases and 152.7 million person-years of follow-up. GBS incidence increased by 20% for every 10-year increase in age; the risk of GBS was higher for males than females. The regression equation for calculating the average GBS rate per 100,000 person-years as a function of age in years was exp[-12.0771 + 0.01813(age in years)] × 100,000. Our findings provide a robust estimate of background GBS incidence in Western countries. Our regression model may be used in comparable populations to estimate the background age-specific rate of GBS incidence for future studies.

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    Article: Identification of Gene Networks and Pathways Associated with Guillain-Barré Syndrome
    Kuo-Hsuan Chang, Tzi-Jung Chuang, Rong-Kuo Lyu, Long-Sun Ro, Yih-Ru Wu, Hong-Shiu Chang, Chin-Chang Huang, Hung-Chou Kuo, Wen-Chuin Hsu, Chun-Che Chu, Chiung-Mei Chen
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    ABSTRACT: Background The underlying change of gene network expression of Guillain-Barré syndrome (GBS) remains elusive. We sought to identify GBS-associated gene networks and signaling pathways by analyzing the transcriptional profile of leukocytes in the patients with GBS. Methods and Findings Quantitative global gene expression microarray analysis of peripheral blood leukocytes was performed on 7 patients with GBS and 7 healthy controls. Gene expression profiles were compared between patients and controls after standardization. The set of genes that significantly correlated with GBS was further analyzed by Ingenuity Pathways Analyses. 256 genes and 18 gene networks were significantly associated with GBS (fold change ≥2, P
    PLoS ONE 01/2012; 7(1). · 4.09 Impact Factor
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    Article: Declining Guillain-Barré syndrome after campylobacteriosis control, New Zealand, 1988-2010.
    Michael G Baker, Amanda Kvalsvig, Jane Zhang, Rob Lake, Ann Sears, Nick Wilson
    [show abstract] [hide abstract]
    ABSTRACT: Infection with Campylobacter spp. commonly precedes Guillain-Barré syndrome (GBS). We therefore hypothesized that GBS incidence may have followed a marked rise and then decline in campylobacteriosis rates in New Zealand. We reviewed records for 1988-2010: hospitalization records for GBS case-patients and campylobacteriosis case-patients plus notifications of campylobacteriosis. We identified 2,056 first hospitalizations for GBS, an average rate of 2.32 hospitalizations/100,000 population/year. Annual rates of hospitalization for GBS were significantly correlated with rates of notifications of campylobacteriosis. For patients hospitalized for campylobacteriosis, risk of being hospitalized for GBS during the next month was greatly increased. Three years after successful interventions to lower Campylobacter spp. contamination of fresh poultry meat, notifications of campylobacteriosis had declined by 52% and hospitalizations for GBS by 13%. Therefore, regulatory measures to prevent foodborne campylobacteriosis probably have an additional health and economic benefit of preventing GBS.
    Emerging Infectious Diseases 02/2012; 18(2):226-33. · 6.79 Impact Factor
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Keywords

1,683 nonduplicate citations
 
152.7 million person-years
 
accepted GBS case definition
 
average GBS rate
 
background age-specific rate
 
background GBS incidence
 
case ascertainment
 
estimate age-specific GBS incidence
 
future studies
 
GBS diagnosis
 
GBS epidemiology
 
GBS incidence
 
Guillain-Barré syndrome
 
inclusion criteria
 
North America
 
random-effects negative binomial regression model
 
regression equation
 
regression model
 
subject matter experts
 
Western countries
 

James J Sejvar