Childhood predictors of use and costs of antidepressant medication by age 24 years: findings from the Finnish Nationwide 1981 Birth Cohort Study.
ABSTRACT Prior studies on antidepressant use in late adolescence and young adulthood have been cross-sectional, and prospective associations with childhood psychiatric problems have not been examined. The objective was to study the association between childhood problems and lifetime prevalence and costs of antidepressant medication by age 24 years.
A total of 5,547 subjects from a nation-wide birth cohort were linked to the National Prescription Register. Information about parent- and teacher-reported conduct, hyperkinetic and emotional symptoms, and self-reported depressive symptoms was gathered at age 8 years. The main outcome measure was national register-based lifetime information about purchases of antidepressants between ages 8 and 24 years. In addition, antidepressant costs were analyzed using a Heckman maximum likelihood model.
In all, 8.8% of males and 13.8% of females had used antidepressants between age 13 and 24 years. Among males, conduct problems independently predicted later antidepressant use. In both genders, self-reported depressive symptoms and living in other than a family with two biological parent at age 8 years independently predicted later antidepressant use. Significant gender interactions were found for conduct and hyperkinetic problems, indicating that more males who had these problems at age 8 have used antidepressants compared with females with the same problems.
Childhood psychopathology predicts use of antidepressants, but the type of childhood psychopathology predicting antidepressant use is different among males and females.
SourceAvailable from: helda.helsinki.fi
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ABSTRACT: Objective. To study predictive associations between psychosocial factors at age 8 and becoming a mother under the age of 20. Design: Prospective follow-up study. Setting: Finland. Population. 2867 girls born in 1981. Methods. Information on family background and psychiatric symptoms was collected at age 8. The associations between these factors and becoming a teenage mother were analyzed using logistic regression analysis. Main outcome measures. Data on births by the age of 20 collected from the hospital discharge register. Results. 128 girls (4.8%) had given birth at the age of 15-19 years. Childhood conduct problems and hyperactive problems, having young mother and family structure other than two biological parents had an independent association with becoming a teenage mother. Conclusions. Girls with externalizing type of problems in childhood have an increased risk of becoming teenage mothers. These problems may also complicate their motherhood.Acta Obstetricia Et Gynecologica Scandinavica 08/2012; 91(11). DOI:10.1111/j.1600-0412.2012.01517.x · 1.99 Impact Factor
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ABSTRACT: Background: Psychosis and other psychiatric disorders are often preceded by prodromal symptoms. There are few community-based studies on symptom predictors of severe mental problems in healthy people. Aims: We aimed to study how a new self-reported screen for prodromal symptoms (PROD) predicts onset of all psychotropic and antipsychotic medication in healthy draftees. Methods: In a prospective follow-up study, 2330 18-year-old Finnish draftees who at call-up in 1999 completed the PROD comprising 21 symptom items divided into positive, negative and general symptom categories were prospectively followed for 6 years. First purchases of any psychotropic and antipsychotic drugs separately between 2000 and 2005 were used as an indicator of the onset of psychiatric disorder and predicted by PROD symptoms in Cox regression analysis. Results: A majority of the PROD items significantly predicted the first purchases of any psychotropic and of antipsychotic drugs, separately. Positive, negative and general symptoms predicted purchases of any psychotropic medication, while negative and general symptoms predicted purchases of antipsychotic drugs. General symptoms, in particular anxiety, had a strong independent association with onset of psychotropic medication. Conclusions: In young healthy men, self-reported sub-clinical psychic symptoms predict onset of psychiatric disorders requiring psychotropic, including antipsychotic, medication.Nordic journal of psychiatry 12/2012; 67(5). DOI:10.3109/08039488.2012.745598 · 1.50 Impact Factor