The role of immune semaphorins in multiple sclerosis

Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan.
FEBS letters (Impact Factor: 3.17). 03/2011; 585(23):3829-35. DOI: 10.1016/j.febslet.2011.03.033
Source: PubMed


The nervous and immune systems have similar functional characteristics. Both have an intricate network of synaptic connections and an exquisite communication system that enable intercellular signal transduction. Although semaphorins were originally identified as guidance cues in neural development, accumulating evidence indicates that several semaphorins called 'immune semaphorins', such as Sema3A, 4A, 4D, 6D and 7A, are critically involved in various phases of the immune response by regulating immune cell-cell contacts or cell migration. In this review, we present recent knowledge on the functions of semaphorins and their receptors in the immune system and their potential roles in the pathogenesis of multiple sclerosis (MS), a representative CNS autoimmune disease, and its animal model, experimental autoimmune encephalomyelitis (EAE).

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Available from: Tatsusada Okuno, Mar 18, 2014
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    • "In another study, the known immunosuppressive function of bone marrow mesenchymal stem cells (MSCs) was attributed in part to their ability to secrete sema3A which, by binding to NP-1, was found to inhibit T cell proliferation [17]. Becoming a frontier player in the regulation of immune responses and the maintenance of self-tolerance, sema3A should be expected to be involved in the pathogenesis of many autoimmune diseases [18,19]. The study by Catalano [20] was the first to report on the defective expression of sema3A in CD4 T cells derived from patients with rheumatoid arthritis (RA). "
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