Article

Natural product biosynthesis inspired concise and stereoselective synthesis of benzopyrones and related scaffolds.

Max-Planck-Institut für molekulare Physiologie, Otto-Hahn Strasse 11, 44227-Dortmund, Germany.
Organic Letters (impact factor: 5.86). 03/2011; 13(8):1988-91. DOI:10.1021/ol200389p pp.1988-91
Source: PubMed

ABSTRACT A natural product biosynthesis-inspired strategy to explore biologically relevant chemical space is presented. A phosphine-catalyzed cascade and stereoselective annulation provides a common tricyclic benzopyrone intermediate that was efficiently transformed into diverse and related naturally occurring scaffolds.

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Keywords

biologically relevant chemical space
 
natural product biosynthesis-inspired strategy
 
stereoselective annulation
 

Baburaj Baskar