Reproductive biology: Progesterone's gateway into sperm.

Nature (Impact Factor: 42.35). 03/2011; 471(7338):313-4. DOI: 10.1038/471313a
Source: PubMed

ABSTRACT The hormone progesterone rapidly activates intracellular signalling in human sperm, regulating key aspects of their physiology. An ion channel unique to the sperm tail seems to relay progesterone's signal. See Letters p.382 & p.387

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    • "When human spermatozoa are exposed to progesterone stimulation , the CatSper channels are directly activated and the calcium stores can be indirectly motivated by progesterone (Koulen et al., 2008; Publicover et al., 2007; Strünker et al., 2011). The Ca 2 þ diffusion due to its concentration difference will induce the intracellular Ca 2 þ dynamic response in spermatozoa. "
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