The Value of Cod Liver Oil and Tomato Juice in the Prophylaxis of Intestinal Tuberculosis.
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ABSTRACT: 1. Seventy-two adult guinea pigs were fed tuberculous sputum daily for periods ranging from 6 weeks to 4 months. 2. Thirty-seven of these were maintained on a diet partially deficient in vitamin C; twenty-six developed ulcerative intestinal tuberculosis. 3. In the remaining thirty-five animals whose diet was supplemented by an adequate amount of vitamin C only two developed tuberculous ulcers in the intestines. 4. From these studies we conclude that the ingestion of tubercle bacilli by the guinea pig is not the sole factor in the production of intestinal tuberculosis. 5. In our opinion, an adequate supply of vitamin C usually protects the guinea pig against ulcerative intestinal tuberculosis.Journal of Experimental Medicine 09/1933; 58(4):503-12. · 13.21 Impact Factor
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ABSTRACT: Some years ago, it occurred to us that the reason tuberculous enteritis was so generally fatal was the fact that it was impossible by any medical means to give the intestine sufficient functional rest to enable it to resist and possibly to recover from its tuberculous lesions. Archibald1 has shown what may be accomplished by proper surgical measures in carefully selected cases. For these reasons it has seemed to us wise to emphasize certain data, not particularly new, but certainly very little known, which may suggest the presence of tuberculosis of the large intestine, and thus aid in its early diagnosis. We shall not attempt to discuss the treatment of this condition, but refer those who are interested to Archibald's former article and to his forthcoming monograph on this subject. It might be added, however, that for surgical interference to be of any help, the diagnosis must be madeJournal of the American Medical Association 73(2):77-85.
THE VALUE OF COD LIV'ER OIL AND TOMATO JUICE IN
THE PROPHYLAXIS OF INTESTINAL TUBERCULOSIS.
By M1ACK McCONKEY, M.D.,
New York State Hospital for Incipient Pulmonary Tuberculosis,
RAY BROOK, N. Y.
The administration of cod liver oil and either tomato juice or
orange juice alleviates the symptoms of intestinal tuberculosis,' and
experimentally tomato juice prevents ulcerative intestinal tuberculosis
These cli'nical and experimental observations sug-
gested the use of cod liver oil and tomato juice to prevent the occur-
rence of intestinal tuberculosis complicating, pulmonary tuberculosis.
At Ray Brook the remedy has been used for this purpose during the
past eleven years, and the results are herepresentedl.
'Until the roentgenologyical studies of Brown and Sampson in
1919,3 autopsy studies revealed that intestinal tuberculosisfrequently
logically the intestinal tracts of 141 patients, of whom I111 were in the
moderately advanced and 30 in the far advanced stages of pulmonary
tuberculosis at the time of their admission to Trudeau Sanatorium.
They found evidence of intestinal ulceration in 40 instances, or28%o.
In 1928 at Ray Brook, 32, or 16%/ of 196 patients, of whom 167 were
in the moderately advanced and 29 in the far advanced stages of the
disease presented evidence of intestinal ulceration on admission as
(letermined by the roentgenological procedure of Brown andSampson.
During the past eleven years, the nuimber of patients comingr to
Ray Brook with intestinal uilceration has gradually declined from
16% in 1928 to 3~/c in 1938 (Table 1). It is of interest that the inci-
dence for the year 1938 is approximately the same for Trudeau* and
Attendant with this decline, there has been a notable rise in the
sale of cod liver oil, tomato and citrus fruit juices as shown by the
figures kindly furnished us by the United States Department of Agri-
culture (Table 2). The sale of tomato juice alone has increased 77-
*Personal communication from Dr. HomerL. Sampson.
TH-E INCIDENCE, OF INTERTINAL ULCERATION FROMI 1928 TO 1938 INCLUSIVE AMIONG
PATIENTS IN THE MODERATELY AND FAR ADVANCED STAGES OF PULMTONARY
TUBERCULOSIS AT TH-E TIME OF ADMNISSION To RAY BROOK.
Total Patients Examined
1928 ............ 196
1936 ............ 182
32, or 16.3%
29, or 14.2%
20, or 9.9%
21, or 10.0%
25, or 10.7%
10, or 5.1%
THE SALE OF TOMAI.TO, FRUL.IT JUICES AND COD LIV-ER OIL FROMI 1929 TO 1937
INCLUSIVE. FIGURES. KINDLY FURISIIED) BY U. S. DEPARTMENT
the past nine
The figures for cod liver
striking, explained in part at least by
the substitution of concentrates
and other fish liver oils.
In recenit years, foods which possess a thera-
peutic and prophylactic value in intestinal tuberculosis have been used
generally and in increasing
amountsby the patients before enter-
and the decline in the incidence of the complica-
tion may be attributed to this factor.
is revealed more clearly
of patients who showed
Cod Liver Oil
V'ALUE OF COD LIVEIR OIL AND TO-MATO JUICE IN TUBERCULOSIs
Do evidence of intestinal tuiberculosis by X-ray examination at the
time of their adlmission to Ray Brook, but who developed symptoms
of intestinal ulceration while undler ouir observation. For example, the
remedy was not given as a prophylactic measure in 1927. In this year
there wiere 214 patients, 193 in the mnoderately advanced and 21 in
the far advanced stagyes of pulmonary tuberculosis, who were treated
at the sanatorium for a period averaging nine months. In this group
of 214 patients, 23.,or approximately 10%/, first developed definite
symptoms of intestinal ulceration while uinder our observation. The
diagnosis was later confirmed by X-ray examination.
11312 patients were observed from 1928 to 1938 inclusive, 1002 in the
mioderately advanced and 310 in the far advanced stagyes of pul-
monarv tuibercuilosis, who likewise showed no evidence on admission
of intestinal ulceration by X-rav examination. All the patients in this
g,roup received half an ouince of cod liver oil and three ounces of either
orangre or tomato juice after each meal during their entire period of
treatment, ax'erag,ing, eight months. Of the 1312 l)atients, 11, or ap-
proximately 1% first developed definite symptoms of intestinal ulcer-
patients, received some form of collapse therapy.
In other words, in 1927, 10%/ of our patients in the moderately
andI far adv'anced stages of the disease first developedI symptoms of
intestinal tuiberculosis while under our observation, but in the follow-
ing yea, 1928, it dropped to1/4 and has remained at this level up
to the present time.
In considlering the reasons for this decline during the past eleven
years,it is to be noted that at RZay Brook there has been no apprecia-
ble chang,e in the rouitine sanatorium treatment, includingy the diet,
of thelpatientsduring the past twenty years, aside from the introduc-
tion of heliotherapv, collapse therapy and the administration of codl
liv~er oil and tomiato juice. Heliotherapy may be dismissed, as it was not
employ'ed as a preventive measuire in intestinal tuberculosis. It is pre-
sumne(l that collapse therapy prevents intesti-nal tuberculosis by free-
ing, the sputum of tuibercle bacilli.
approximately~40%/( received some form of collapse therapy and in
somewhat less than 5%of instances the sputum was renderedl free of
tuibercle bacilli by this method of treatment. Collapse therapy, there-
In this series of 11312 patients,
fore, cannot reasonably he regarded as an important factor in the
marked decline of intestinal symptoms in this group. Finally, if col-
lapse therapy were the important factor, the decline should have been
restricted to the group receiving collapse therapy, but in reality the
(lecline occurred to the same extent among the patients who did and
those who did not receive collapse therapy.
At Ray B3rook, the use of cod liver oil and tomato juice as a
prophylactic measure in intestinal tuberculosis was started in 1928,
the year in which an abrupt decline occurred in the development of
intestinal symptoms among, our patients from 10% in 1927 to 1%, in
1928. The remedy has been used for this purpose to the present time
and there has been no change in the incidence of intestinal symptoms
developingy among our patients, irrespective of whether they had or
had not receivedl collapse therapy.
It seems justifiable, therefore, to concluide that the administra-
tion of this remedy is a valuable measure in the prevention of intes-
tinal tuberculosis. WNith this point in mind during, the past five years,
our pa-tients, for psychological reasons, have not been warned of the
danger of swallowing their sputum; yet during this period there was
no increase in the number of patients developing, symptoms of intes-
Conversely, the lack of cod liver oil and tomato juice, or their
equivalents in the diet, is associated with a high incidence of intestinal
ulceration complicating, pulmonary tuberculosiS,
recent figyures of Burke and Aronovitch.* Their patients did not re-
ceive cod liver oil and tomato juice or their equivalents in adequate
amounts, and in a series of 226 patients examined by them in 1938
they found intestinal ulceration as determined by X-ray present in
71, or 31%/(, figures comparable to those of Brown and Sampson in
Thirty-three patients died at Ray Brook of advanced pulmonary
tuberculosis who had not received cod liver oil and tomato juice. Of
this number, 29, or 88%, presented ulcers of the intestines. Dr. Oscar
Auerbach has kindly furnished us with the following figures concern-
ing the incidence of intestinal tuberculosis at Sea View Hospital:
'During the year 1938, there were 143 cases of straight chronic pul-
as shown by the
VALUE OF COD LIVER OIL AND TOMATO JUICE IN TUBERCULOSIS
monary tuberculosis which we autopsied. Of these, 34, or 22.8%0,
had no intestinal tuberculosis, while 109 (77.2%) had intestinal
tuberculosis. A number of patients received cod liver oil, but there
was no regularity in this treatment." Burke and Aronovitch at the
Grace Dart Hospital in Montreal, in a series of 109 autopsies on sub-
jects who had died of advanced pulmonary tuberculosis, found ulcera-
tion of the intestines in 76, or 70%.
It is interesting to note that these necropsy figures concerning the
incidence of intestinal tuberculosis among patients who did not re-
ceive cod liver oil and tomato juice are comparable to those of Louis,4
who in 1825 found ulcerative intestinal tuberculosis in 82%0 of 125
autopsies on tuberculous subjects.
However, in a small series of 20 patients who died at Ray Brook
of advanced pulmonary tuberculosis and who had received cod liver
oil and tomato juice, only 6, or 30%s, presented tuberculous ulceration
of the intestines at necropsy. In 80 consecutive autopsies on tuber-
culous subjects by Dr. Gardner and Dr. Vorwald* of the Saranac Lake
Laboratory between the years 1930 and 1934 inclusive, ulceration of
the intestines occurred in 61 %, while in 80 consecutive autopsies
between 1935 and 1939 inclusive, the incidence dropped to 41%. The
decline in the incidence of intestinal tuberculosis in this last five-year
period may be ascribed to the more frequent administration of cod
liver oil and tomato juice, or their equivalents.
The conclusion seems justified from clinical and necropsy studies,
that the administration of cod liver oil and tomato juice is a valuable
prophylactic measure in intestinal tuberculosis and should be pre-
scribed for all patients with pulmonary tuberculosis.
1. MCCONKEY, MACK: The Treatment of Intestinal Tuberculosis with Cod
Liver Oil and Tomato Juice. American Rev. Tb., 1930, 21, 627.
2. MCCONKEY, MACK, AND SMITH, DAVID T.: The Relation of Vitamin C Defi-
ciency to Intestinal Tuberculosis in the Guinea Pig. Jour. Experimental
Medicine, 1933, 58, 503.
3. BROWN, LAWRASON, AND SAMPSON, HOMER L.: The Early Roentgen Diagnosis
of Ulcerative Tuberculous Colitis. American Jour. Roentgenology, 19,19,
4. Louis, P. C. A., quoted by Brown & Sampson on page 106 of their book on
Intestinal Tuberculosis, Diagnosis and Treatment.
Lea & Febiger, 1926.