Effects of Stress on Decision-Making Deficits in Formerly Heroin-Dependent Patients After Different Durations of Abstinence

National Institute on Drug Abuse, Роквилл, Maryland, United States
American Journal of Psychiatry (Impact Factor: 12.3). 03/2011; 168(6):610-6. DOI: 10.1176/appi.ajp.2010.10040499
Source: PubMed


Drug abuse is associated with substantial impairments in decision making. However, little is known about the time course of changes in decision-making ability after abstinence or about the effects of stress on decision making in individuals recovering from heroin dependence after different durations of abstinence.
First, the authors assessed decision-making performance with the original card version of the Iowa Gambling Task in formerly heroin-dependent patients who had been abstinent for 3, 7, 15, or 30 days or 3, 6, 12, or 24 months. Second, patients who had been abstinent from heroin for 15 or 30 days or 3, 12, or 24 months were challenged with acute stress induced by the Trier Social Stress Test. Third, the β-adrenoceptor antagonist propranolol (40 mg) was administered 1 hour before stress to those who had been abstinent for 30 days or 12 or 24 months.
The short-term abstinence groups (3-30 days) performed worse on the Iowa Gambling Task compared with the long-term abstinence groups (3-24 months). Psychosocial stress unmasked a latent impairment in decision making in the 24-month abstinence group, which seemed to perform identically to healthy comparison subjects in the absence of stress. Propranolol blocked the stress-induced impairment of decision making, which was seen only in the formerly heroin-dependent patients.
Stress can exacerbate an already existing impairment of decision making or unmask a latent one in individuals recovering from heroin dependence. The β-adrenergic blockade reduces this effect and might hold promise for treatment of substance use disorders.

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    • "Affective decision-making deficits have been reported among individuals with different forms of substance use disorder (e.g., alcohol, marijuana and cocaine; Barry and Petry, 2008; Bechara et al., 2001; Bechara and Damasio, 2002; Bechara and Martin, 2004; Fernández- Serrano et al., 2010; Noël et al., 2007; Verdejo-García et al., 2007). Heroin addicts have also been found to reveal severe affective decision-making impairments (Fishbein et al., 2007; Vassileva et al., 2007; Zhang et al., 2011). Interestingly, pathological gamblers have shown impaired performance on decision-making tasks as well (Cavedini et al., 2002; Goudriaan et al., 2005, 2006; Lawrence et al., 2009b). "
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    ABSTRACT: Cognitive deficits are observed both in heroin dependence and in pathological gambling (PG) on various tasks. PG, as a non-substance addiction, is free of toxic consequences of drug use. Therefore a direct neurocognitive comparison of heroin addicts and pathological gamblers helps dissociate the consequences of chronic heroin use on cognitive function from the cognitive vulnerabilities that predispose addiction. A case-control design was used, comparing 58 abstinent heroin addicts, 58 pathological gamblers, and 60 healthy controls on working memory and affective decision-making functions. Working memory was assessed using the Self-ordered Pointing Test (SOPT). Affective decision-making was measured by the Iowa Gambling Task (IGT). Heroin addicts performed significantly worse both on the IGT and on the SOPT, compared to healthy controls. Pathological gamblers performed worse on the IGT than healthy controls, but did not differ from controls on the SOPT. Years of heroin use were negatively correlated with working memory and affective decision-making performance in heroin addicts, while severity of gambling was not significantly correlated with any task performance in pathological gamblers. Our findings indicate that deficits in affective decision-making shared by heroin dependence and PG putatively represent vulnerabilities to addiction and that working memory deficits detected only in heroin addicts may be identified as heroin-specific harmful effects.
    Drug and alcohol dependence 10/2013; 134(1). DOI:10.1016/j.drugalcdep.2013.09.027 · 3.42 Impact Factor
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    • "Neuropsychological and personality research indicated that addiction is associated with elevated scores on questionnaires that measure impulsivity and impaired performance on laboratory tasks of impulsivity [11], [12], [13], [14]. The behavioral analysis of impulsivity in humans has predominantly used three paradigms: decision-making, response inhibition, and reflection impulsivity [14]. "
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    ABSTRACT: The majority of drug abusers are incapable of sustaining abstinence over any length of time. Accumulating evidence has linked intense and involuntary craving, Impulsive decision-making and mood disturbances to risk for relapse. However, little is known about temporal changes of these neuropsychological functions in methamphetamine (METH)-dependent individuals. To investigate the effect of length of abstinence on decision-making, craving (baseline and cue-induced), and emotional state in METH-addicted individuals. In this cross-sectional study, 183 adult METH-dependent patients at an addiction rehabilitation center who were abstinent for 6 days (n = 37), 14 days (n = 33), 1 month (n = 31), 3 months (n = 30), 6 months (n = 26), or 1 year (n = 30) and 39 healthy subjects were administered the Iowa Gambling Task (IGT) to assess decision-making performance. Depression, anxiety, and impulsivity were also examined. One hundred thirty-nine METH abusers who were abstinent for the aforementioned times then underwent a cue session, and subjective and physiological measures were assessed. METH dependent individuals who were abstinent for longer periods of time exhibited better decision-making than those who were abstinent for shorter periods of time. And self-reported emotional symptoms improved with abstinence. METH abusers' ratings of craving decreased with the duration of abstinence, while cue-induced craving increased until 3 months of abstinence and decreased at 6 months and 1 year of abstinence. We present time-dependent alterations in decision-making, emotional state, and the incubation of cue-induced craving in METH-dependent individuals, which might have significant clinical implications for the prevention of relapse.
    PLoS ONE 07/2013; 8(7):e68791. DOI:10.1371/journal.pone.0068791 · 3.23 Impact Factor
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    • "Finally, it has been recently reported that, in former heroin addicts, stress induction can reveal a latent decision-making impairment (Zhang et al., 2011). Altogether these findings may suggest the need of a fine balance between the negative and positive effects of stress for optimum decision-making abilities. "
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    ABSTRACT: Decision-making impairment is found in several neuropsychiatric disorders, including suicidal behavior, and has been shown to be modulated by genes. On the other hand, early trauma have/has been associated with poor mental health outcome in adulthood, in interaction with genetic factors, possibly through sustained alterations in the hypothalamic-pituitary-adrenal axis (HPA axis). Here, we aimed to investigate the effect of childhood trauma and its interaction with HPA-axis related genes on decision-making abilities in adulthood among a sample of suicide attempters. The Iowa Gambling Task (IGT) was used to assess decision-making in 218 patients with a history of suicide attempt. Participant fulfilled the Childhood Trauma Questionnaire to report traumatic childhood experiences. Patients were genotyped for single-nucleotide polymorphisms within CRHR1 and CRHR2 genes. Patients with a history of sexual abuse had significantly lower IGT scores than non-sexually abused individuals. Polymorphisms within CRHR1 and CRHR2 genes interacted with both childhood sexual abuse and emotional neglect to influence IGT performance. In conclusion, childhood sexual abuse and emotional neglect may have long-term effects on decision-making through an interaction with key HPA axis genes. Even if these results need to be replicated in other sample, impaired decision-making may thus be the dimension through which child maltreatment, in interaction with HPA axis related genes, may have a sustained negative impact on adult mental health.
    Journal of Psychiatric Research 11/2012; 47(2). DOI:10.1016/j.jpsychires.2012.10.014 · 3.96 Impact Factor
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