A systematic review of medical interventions for oral submucous fibrosis and future research opportunities.
ABSTRACT Oral Diseases (2011) 17 (Suppl. 1), 42-57 Oral submucous fibrosis (OSF) is a chronic, insidious disease caused by areca nut use, and is associated with both significant morbidity (including pain and reduced oral opening) and an increased risk for malignancy. This systematic review explored and updated the current medical (i.e., non-surgical) interventions available for the management of OSF. Of the 27 published medical interventions, there were four randomized controlled trials. The overall quality of these randomized controlled studies was assessed using the GRADE approach and significant limitations that challenged the conclusions were found. However, this review was valuable in terms of identifying opportunities to provide recommendations for future research, in terms of the populations to research, the types of interventions needed, the types of outcomes to be measured, the study designs needed, and the infrastructure required to conduct studies. The next step is to initiate a pathway for a low-cost research plan leading to the development of a brief protocol for future clinical trials in this field, with an emphasis on conducting studies in regions of the world where OSF is prevalent.
- SourceAvailable from: Prakash C Gupta[show abstract] [hide abstract]
ABSTRACT: Abstract Sixty-six patients with oral submucous fibrosis were followed-up for a period of 17 yr (median observation 10 yr) in Ernakulam District, Kerala, India. Oral cancer developed in five (7.6%) patients. The malignant transformation rate in the same sample was 4.5% over a 15-yr observation period (median 8 yr). These findings impart a high degree of malignant potential to this condition.Community Dentistry And Oral Epidemiology 11/1985; 13(6):340 - 341. · 1.80 Impact Factor
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ABSTRACT: A rare case of oral submucous fibrosis in a 4-year-old Indian girl is presented. The condition is defined, and the clinical and laboratory features are discussed. Different treatment modalities and current theories of etiology are presented. Finally, the importance of regarding this condition as a precancerous lesion is supported.Oral Surgery Oral Medicine Oral Pathology 06/1985; 59(5):475-8.