Article

Inferring protein function from homology using the Princeton Protein Orthology Database (P-POD).

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA.
Current protocols in bioinformatics / editoral board, Andreas D. Baxevanis ... [et al.] 03/2011; Chapter 6:Unit 6.11. DOI:10.1002/0471250953.bi0611s33 pp.Unit 6.11
Source: PubMed

ABSTRACT Inferring a protein's function by homology is a powerful tool for biologists. The Princeton Protein Orthology Database (P-POD) offers a simple way to visualize and analyze the relationships between homologous proteins in order to infer function. P-POD contains computationally generated analysis distinguishing orthologs from paralogs combined with curated published information on functional complementation and on human diseases. P-POD also features an applet, Notung, for users to explore and modify phylogenetic trees and generate their own ortholog/paralogs calls. This unit describes how to search P-POD for precomputed data, how to find and use the associated curated information from the literature, and how to use Notung to analyze and refine the results.

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Keywords

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human diseases
 
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precomputed data
 
Princeton Protein Orthology Database
 
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