Coffee Consumption and Risk of Stroke in Women

Division of Nutritional Epidemiology, National Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE-17177 Stockholm, Sweden.
Stroke (Impact Factor: 5.72). 03/2011; 42(4):908-12. DOI: 10.1161/STROKEAHA.110.603787
Source: PubMed


Coffee consumption has been inconsistently associated with stroke incidence and mortality in previous studies. We investigated the association between coffee consumption and stroke incidence in the Swedish Mammography Cohort.
We prospectively followed of 34,670 women without a history of cardiovascular disease or cancer at baseline in 1997. Coffee consumption was assessed in 1997 using a self-administered questionnaire. Incident stroke cases were ascertained from the Swedish Hospital Discharge Registry.
During a mean follow-up of 10.4 years, we ascertained 1680 stroke events, including 1310 cerebral infarctions, 154 intracerebral hemorrhages, 79 subarachnoid hemorrhages, and 137 unspecified strokes. After adjustment for other risk factors, coffee consumption was associated with a statistically significant lower risk of total stroke, cerebral infarction, and subarachnoid hemorrhage but not intracerebral hemorrhage. The multivariable relative risks of total stroke across categories of coffee consumption (<1 cup/day, 1 to 2 cups/day, 3 to 4 cups/day, and ≥5 cups/day) were 1.00, 0.78 (95% CI, 0.66 to 0.91), 0.75 (95% CI, 0.64 to 0.88), and 0.77 (95% CI, 0.63 to 0.92, respectively; P for trend=0.02). The association between coffee consumption and cerebral infarction was not modified by smoking status, body mass index, history of diabetes or hypertension, or alcohol consumption.
These findings suggest that low or no coffee consumption is associated with an increased risk of stroke in women.

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Available from: Alicja Wolk, Oct 13, 2015
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    • "In agreement, Larsson and Orsini [197] reported that it is the moderate coffee consumption (3-4 cups/day) that reduces the risk of stroke. Additionally, one study showed that coffee consumption (more than 4 cups/day) in men was not associated with increased risk of stroke [198] while studies performed in Swedish and USA women have indicated that habitual intake of coffee (from 1 to 5 or more cups/day) was associated with a statistically significant lower risk of total stroke [199], cerebral infarction, and subarachnoid hemorrhage but not intracerebral hemorrhage [200]. In contrast, an epidemiological study showed that neither the high (more than 4 cups/day) nor the low doses (less than 2 cups/day) have the most dangerous effect but it is the intermediate consumption (2–4 cups/day) of coffee which can be the most harmful [201]. "
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    • "Fourthly, subgroup analysis was conducted according to results. Two13,20) of the included papers categorized results into stroke, cerebral infarction, and cerebral hemorrhage. Thus, the RRs of cerebral infarction of the two papers were combined with that of one other paper,12) in which the outcome was cerebral infarction, for analysis. "
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