Article

Dietary fat, fiber, and carbohydrate intake in relation to risk of endometrial cancer.

Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Cancer Epidemiology Biomarkers &amp Prevention (impact factor: 4.12). 03/2011; 20(5):978-89. DOI:10.1158/1055-9965.EPI-10-1089 pp.978-89
Source: PubMed

ABSTRACT Macronutrients such as fat and fiber have been hypothesized to play a role in the etiology of endometrial cancer.
To investigate these associations, the authors analyzed data from the Nurses' Health Study. From 1980 to 2006, 669 invasive adenocarcinoma cases were identified over 1.3 million person-years of follow-up. Dietary intake was assessed in 1980 and updated every 2-4 years. Cox proportional hazard models were used to calculate relative risks (RRs), controlling for total energy and other risk factors.
Overall, the authors found no significant associations between most dietary factors and endometrial cancer risk. Total fat was associated with a borderline significant decreased risk (top vs. bottom quintile RR = 0.78; 95% CI = 0.60-0.99; P(trend) = 0.18). Findings for animal fat were similar. No inverse associations between dietary fibers and cancer risk were observed. Cereal fiber was modestly positively associated with risk (top vs. bottom quintile RR = 1.38, 95% CI = 1.07-1.79; P(trend) = 0.05). The inverse association with animal fat intake and a positive association with carbohydrate intake were observed among premenopausal but not among postmenopausal women.
In this large prospective study, no overall association was observed between dietary fat, fiber, and carbohydrates with endometrial cancer risk, although several of the relationships may vary by menopausal status.
Dietary fat and fiber intake do not seem to play a major role in endometrial cancer etiology overall. However, further evaluation of these associations, particularly in premenopausal women, is needed.

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Keywords

animal fat
 
animal fat intake
 
calculate relative risks
 
carbohydrate intake
 
dietary factors
 
Dietary fat
 
Dietary intake
 
endometrial cancer
 
endometrial cancer etiology
 
fiber intake
 
inverse association
 
large prospective study
 
major role
 
menopausal status
 
Nurses' Health Study
 
positive association
 
postmenopausal women
 
premenopausal women
 
risk factors
 
Total fat