Start » Publications

Gene expression profiles in peripheral blood for the diagnosis of autoimmune diseases.

Bertalan Mesko, Szilard Poliska, Laszlo Nagy

Department of Biochemistry and Molecular Biology, Research Center for Molecular Mediicne, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary.

Journal Article: Trends in Molecular Medicine (impact factor: 11.05). 03/2011; 17(4):223-33. DOI: 10.1016/j.molmed.2010.12.004

Abstract

Gene expression profiling in clinical genomics has yet to deliver robust and reliable approaches for developing diagnostics and contributing to personalized medicine. Owing to technological developments and the recent accumulation of expression profiles, it is a timely and relevant question whether peripheral blood gene expression profiling can be used routinely in clinical decision making. Here, we review the available gene expression profiling data of peripheral blood in autoimmune and chronic inflammatory diseases and suggest that peripheral blood mononuclear cells are suitable for descriptive and comparative gene expression analyses. A gene-disease interaction network in chronic inflammatory diseases, a general protocol for future studies and a decision tree for researchers are presented to facilitate standardization and adoption of this approach.

Source: PubMed

Comments on this publication

ResearchGate members can add comments. Sign up now and post your comment!

  • Researcher
    vary nice papaer, really i like it very much.............

    Aug 1, 2011 12:11 pm
  • Researcher
    vary nice paper, really i like it very much.............

    Aug 1, 2011 12:11 pm
  • Researcher
    vary nice paper, really i like it very much.............

    Aug 1, 2011 12:11 pm

Similar publications

Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Science & Research Jobs

View jobs

Keywords

chronic inflammatory diseases
 
clinical decision
 
clinical genomics
 
comparative gene expression analyses
 
diagnostics
 
gene-disease interaction network
 
general protocol
 
peripheral blood
 
peripheral blood gene expression profiling
 
peripheral blood mononuclear cells
 
recent accumulation
 
reliable approaches
 
technological developments
 
timely