Quality of life in children and adults with constipation

Division of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, Centennial Building, 4th floor, 1685 Highland Avenue, Madison, WI 53705, United States.
Best practice & research. Clinical gastroenterology (Impact Factor: 3.48). 02/2011; 25(1):19-27. DOI: 10.1016/j.bpg.2010.12.004
Source: PubMed


This review summarises the literature on quality of life (QOL) assessments in both children and adults with functional constipation. Studies of adults with constipation include subjects from both tertiary care centres and population-based surveys whereas there are no population-based studies in children. The preponderance of evidence indicates that the adverse effects of chronic constipation on QOL in both children and adults are comparable to that seen in other chronic gastrointestinal and non-gastrointestinal disorders. There are no data on the effect of treatment of children with constipation with regard to QOL whereas several studies indicate that successful treatment of constipation in adults has a favourable effect on QOL. The emerging concept in the treatment of chronic constipation is to measure both objective measures such as frequency and ease of defecation and subjective parameters such as QOL.

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    • "In these studies, the rate of treatment success ranged from 57% [8] to 67% [9], but there was no difference between the groups in any of the studies. Constipation unfavorably influences the quality of life of affected children [11] [12]. While the goal of treatment of functional constipation is to restore a regular defecation pattern and to prevent relapses, the persistence of symptoms of constipation was reported in 30–52% of children followed up for at least 5 years [13] [14]. "
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    ABSTRACT: Background: The goal of treatment of functional constipation (FC) is to restore a regular defecation pattern and to prevent relapses. Aim: To assess long-term outcomes in children with FC. Methods: This was a follow-up study of children previously enrolled in 2 independent randomized controlled trials. In the first trial, children randomly received glucomannan (GNN) or placebo for 4 weeks. In the second study, children received a fermented dairy product with Bifidobacterium lactis I-2494 (B. lactis) or placebo for 3 weeks. Follow-up data were collected using a standardized questionnaire. The primary outcome measure was treatment success (≥3 spontaneous bowel movements with no episodes of soiling during the last week, abdominal pain, or need for laxatives). The secondary outcomes were FC according to the Rome III criteria and the need for laxative therapy. Results: In the GNN study, follow-up data at 24 months were obtained from 63 of 72 (87.5%) of children. Treatment success was reported in 36/63 (57%), FC in 17/63 (27%), and the need for laxatives in 13/63 (21%). There were no differences in outcomes between groups. In the B. lactis study, follow-up data at 36 months were obtained from 57 of 82 (70%) of children. Treatment success was reported in 26/57 (46%), FC in 21/57 (37%), and the need for laxatives in 15/57 (26%). There were no differences in outcomes between groups. Conclusion: A substantial portion of children remained symptomatic after 2-3 years of follow-up indicating a need for regular evaluation of children with FC. © 2013 Polish Pediatric Society. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.
    Pediatria polska 05/2013; 88(3):219-223. DOI:10.1016/j.pepo.2013.02.005
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    • "The prevalence is higher in females, older individuals, those of lower socioeconomic status, and those with a lower educational level [2,3]. As a common and well-recognized public health problem, functional constipation influences patient quality of life and consumes many healthcare resources [4,5]. "
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    ABSTRACT: Whether acupuncture is effective for patients with functional constipation is still unclear. Therefore, we report the protocol of a randomized controlled trial of using acupuncture to treat functional constipation. A randomized, controlled, four-arm design, large-scale trial is currently undergoing in China. Seven hundred participants are randomly assigned to three acupuncture treatment groups and Mosapride Citrate control group in a 1:1:1:1 ratio. Participants in acupuncture groups receive 16 sessions of acupuncture treatment, and are followed up for a period of 9 weeks after randomization. The acupuncture groups are: (1) Back-Shu and Front-Mu acupoints of Large Intestine meridians (Shu-Mu points group); (2) He-Sea and Lower He-Sea acupoints of Large Intestine meridians (He points group); (3) Combining used Back-Shu, Front-Mu, He-Sea, and Lower He-Sea acupoints of Large Intestine meridians (Shu-Mu-He points group). The control group is Mosapride Citrate group. The primary outcome is frequency of defecation per week at the fourth week after randomization. The secondary outcomes include Bristol stool scale, the extent of difficulty during defecating, MOS 36-item Short Form health survey (SF-36), Self-Rating Anxiety Scale (SAS), and Self-rating Depression Scale (SDS). The first two of second outcomes are measured 1 week before randomization and 2, 4, and 8 weeks after randomization. Other second outcomes are measured 1 week before randomization and 2 and 4 weeks after randomization, but SF-36 is measured at randomization and 4 weeks after randomization. The result of this trial (which will be available in 2012) will confirm whether acupuncture is effective to treat functional constipation and whether traditional acupuncture theories play an important role in it. Clinical NCT01411501.
    Trials 07/2012; 13(1):104. DOI:10.1186/1745-6215-13-104 · 1.73 Impact Factor
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    ABSTRACT: In this study, a unique two-step process, i.e., an oxyfluorination-assisted graft polymerization (OAGP), was used to modify the surface properties of low-density polyethylene (LDPE) films. Based on the results of the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method, which was performed to estimate the amount of hydroperoxides generated by oxyfluorination, oxyfluorination conditions that maximize the amount of hydroperoxide groups were selected. Hydroperoxides were generated by oxyfluorination to provide active sites for the OAGP of the different monomers. Depending on the type of monomers used, two different graft polymerization behaviors were observed. Hydrophilic methacrylic acid (MA) monomers were graft polymerized onto the oxyfluorinated LDPE (OFPE) surface in a perpendicular direction, forming a spike-shaped morphology. On the other hand, hydrophobic styrene (ST) monomers were graft polymerized parallel to the OFPE surface, forming a valley-shaped morphology. By changing the type of vinyl monomers, two different surfaces could be prepared using the hydroperoxides generated by oxyfluorination. After OAGP with MA monomers, a hydrophilic surface following the Wenzel model was obtained, whereas after OAGP with ST monomers, a hydrophobic surface following the Cassie–Baxter model was obtained. Therefore, the OAGP process may be an efficient method for preparing two different surfaces by changing the monomer used.
    Colloids and Surfaces A Physicochemical and Engineering Aspects 01/2011; 373(1-3):36-41. DOI:10.1016/j.colsurfa.2010.10.008 · 2.75 Impact Factor
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