Article

[Clinical impact of HLA disparities in transplants from unrelated donors].

Institut Català d'Oncologia, Hospital Josep Trueta, Gerona, España.
Methods and Findings in Experimental and Clinical Pharmacology (impact factor: 0.93). 12/2010; 32 Suppl A:27-9. pp.27-9
Source: PubMed

ABSTRACT The search for an unrelated donor must be based on the HLA typing of the donor and the host. PCR techniques have facilitated high-resolution HLA typing, but they have also elicited questions about the real impact of the various disparities on the progress of the graft Thus, whereas a donor used to be accepted based on HLA-A and B Identity determined by serology and HLA-DRB1 through molecular biology techniques, now a donor is required to have a 70/70 Identity for loci HLA-A, B, C, DRB7, and DQB7. Furthermore, the real effect of the disparities in the sixth locus of the major histocompatibility complex-HLA-DPBT-is still in doubt. This study intends to conduct a literature review of the clinical impact of the various HLA disparities In transplants from unrelated donors.

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Keywords

B Identity
 
clinical impact
 
DQB7
 
DRB7
 
HLA typing
 
HLA-A
 
HLA-DRB1
 
literature review
 
loci HLA-A
 
major histocompatibility complex-HLA-DPBT-is
 
molecular biology techniques
 
PCR techniques
 
real effect
 
real impact
 
sixth locus
 
unrelated donor
 
unrelated donors
 
various disparities
 
various HLA disparities
 

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